DDR1 antibody (AA 21-176)

Catalog No. ABIN5611283

Product Details anti-DDR1 Antibody

Target: DDR1 (Discoidin Domain Receptor tyrosine Kinase 1 (DDR1))

Binding Specificity: AA 21-176

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This DDR1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Flow Cytometry (FACS), Immunocytochemistry (ICC), Neutralization (Neut)

Purification: purified

Immunogen: Purified recombinant fragment of human CD167 (AA: extra 21-176) expressed in E. coli.

Clone: 4F2C12

Isotype: IgG2b

Application Details

Application Notes: ELISA: 1:10000, WB: 1:500 - 1:2000, ICC: N/A, FCM: 1:200 - 1:400, IHC: N/A

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified antibody in PBS with 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C/-20 °C

Storage Comment: 4°C, -20°C for long term storage

Target Details for DDR1

Target: DDR1 (Discoidin Domain Receptor tyrosine Kinase 1 (DDR1))

Alternative Name: CD167 (DDR1 Products)

Background:

Description: Receptor tyrosine kinases play a key role in the communication of cells with their microenvironment. These kinases are involved in the regulation of cell growth, differentiation and metabolism. The protein encoded by this gene belongs to a subfamily of tyrosine kinase receptors with homology to Dictyostelium discoideum protein discoidin I in their extracellular domain, and that are activated by various types of collagen. Expression of this protein is restricted to epithelial cells, particularly in the kidney, lung, gastrointestinal tract, and brain. In addition, it has been shown to be significantly overexpressed in several human tumors. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.

Aliases: DDR1,CAK, DDR, NEP, HGK2, PTK3, RTK6, TRKE, EDDR1, MCK10, NTRK4, PTK3A

Molecular Weight: 101 kDa

Gene ID: 780

HGNC: 780

Pathways: RTK Signaling, Smooth Muscle Cell Migration