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Details for Product No. ABIN391759

Cyclin-Dependent Kinase 8 (CDK8) (N-Term), (AA 1-30) antibody

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Synonyms K35, wu:fk95h11
»Alternatives N-Term, AA 1-30
»Alternatives Human
»Alternatives Rabbit
Clonality (Clone) Polyclonal ()
»Alternatives Un-conjugated
»Alternatives Western Blotting (WB)
Pubmed 4 references available
Catalog no. ABIN391759
Quantity 400 µL
291.50 $   Plus shipping costs $45.00
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Immunogen This CDK8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 AA from the N-terminal region of human CDK8.
Clone RB3200
Isotype Ig
Specificity This CDK8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 3~32 amino acids from the N-terminal region of human CDK8.
Predicted Reactivity Mouse (Murine)
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Alternative Name CDK8
Background CDK8 is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This kinase and its regulatory subunit cyclin C are components of the RNA polymerase II holoenzyme complex, which phosphorylates the carboxy-terminal domain (CTD) of the largest subunit of RNA polymerase II. This kinase has also been shown to regulate transcription by targeting the CDK7/cyclin H subunits of the general transcription initiation factor IIH (TFIIH), thus providing a link between the 'Mediator-like' protein complexes and the basal transcription machinery.
Synonyms: Cell division protein kinase 8, Protein kinase K35
Molecular Weight 53283 DA
Gene ID 1024
UniProt P49336
Research Area Phospho-specific antibodies, Protein Modifications, Cell Cycle, Transcription Factors, Signaling, Cell Structure
Application Notes Recommend dilutions: WB : 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 2 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Background publications Tassan, Jaquenoud, Léopold et al.: "Identification of human cyclin-dependent kinase 8, a putative protein kinase partner for cyclin C." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 92, Issue 19, pp. 8871-5, 1995 (PubMed).

Rickert, Corden, Lees: "Cyclin C/CDK8 and cyclin H/CDK7/p36 are biochemically distinct CTD kinases." in: Oncogene, Vol. 18, Issue 4, pp. 1093-102, 1999 (PubMed).

Akoulitchev, Chuikov, Reinberg: "TFIIH is negatively regulated by cdk8-containing mediator complexes." in: Nature, Vol. 407, Issue 6800, pp. 102-6, 2000 (PubMed).

Di Pietro, Rapisarda, Bonaiuto et al.: "Genomics of the human genes encoding four TAFII subunits of TFIID, the three subunits of TFIIA, as well as CDK8 and SURB7." in: Somatic cell and molecular genetics, Vol. 25, Issue 3, pp. 185-9, 2001 (PubMed).

Alternatives for antigen "Cyclin-Dependent Kinase 8 (CDK8)", type "Antibodies"
Hosts (38), (9)
Reactivities (46), (29), (21), (13), (13), (1), (1)
Applications (36), (21), (10), (3), (3), (2), (2), (1), (1)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (7), (5), (2), (2), (2), (2), (2), (1), (1), (1), (1)