CDK8 antibody (C-Term)

Catalog No. ABIN6242788

The Rabbit Polyclonal anti-CDK8 antibody (Clone RB51053) (ABIN6242788) specifically detects CDK8 in WB. The antibody is reactive with Human samples.

Quick Overview for CDK8 antibody (C-Term) (ABIN6242788)

Target: CDK8 (Cyclin-Dependent Kinase 8 (CDK8))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CDK8 antibody is un-conjugated

Application: Western Blotting (WB)

Clone: RB51053

Product Details anti-CDK8 Antibody

Binding Specificity: AA 424-458, C-Term

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This Mouse Cdk8 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 424-458 amino acids from the C-terminal region of Mouse Cdk8.

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

Target Details for CDK8

Target: CDK8 (Cyclin-Dependent Kinase 8 (CDK8))

Alternative Name: Cdk8

Background: Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex. Phosphorylates CCNH leading to down-regulation of the TFIIH complex and transcriptional repression. Recruited through interaction with MAML1 to hyperphosphorylate the intracellular domain of NOTCH, leading to its degradation (By similarity).

Molecular Weight: 53210

UniProt: Q8R3L8

Pathways: Cell Division Cycle, Regulation of Lipid Metabolism by PPARalpha