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CDK8 antibody (C-Term)

CDK8 Reactivity: Human, Mouse WB, ChIP-seq, ChIP Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN6971509
  • Target See all CDK8 Antibodies
    CDK8 (Cyclin-Dependent Kinase 8 (CDK8))
    Binding Specificity
    • 9
    • 8
    • 8
    • 7
    • 7
    • 6
    • 4
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term
    Reactivity
    • 76
    • 38
    • 28
    • 7
    • 6
    • 5
    • 5
    • 4
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    Human, Mouse
    Host
    • 72
    • 3
    • 1
    Rabbit
    Clonality
    • 64
    • 12
    Polyclonal
    Conjugate
    • 40
    • 5
    • 4
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    This CDK8 antibody is un-conjugated
    Application
    • 62
    • 29
    • 11
    • 10
    • 9
    • 9
    • 6
    • 3
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), ChIP DNA-Sequencing (ChIP-seq), Chromatin Immunoprecipitation (ChIP)
    Characteristics
    CDK8 (Cyclin-Dependent Kinase 8) is a component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. CDK8 phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex. Other studies have indicated a role in transcriptional activation in response to hypoxia. CDK8 antibody (pAb) was raised in a Rabbit host. It has been validated for use in Chromatin Immunoprecipitation, ChIP-Seq and Western blot, it has been shown to react with Human and Mouse samples.
    Purification
    Affinity Purified
    Immunogen
    This antibody was raised against a peptide within the C-terminal region of human CDK8.
    Isotype
    IgG
    Top Product
    Discover our top product CDK8 Primary Antibody
  • Application Notes
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Buffer
    Purified IgG in PBS with 30 % glycerol and 0.035 % sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage.
  • Target
    CDK8 (Cyclin-Dependent Kinase 8 (CDK8))
    Alternative Name
    CDK8 (CDK8 Products)
    Synonyms
    K35 antibody, wu:fk95h11 antibody, cyclin dependent kinase 8 antibody, cyclin-dependent kinase 8 antibody, cyclin-dependent kinase 8 S homeolog antibody, Cyclin-dependent kinase 8 antibody, cyclin dependent kinase 19 antibody, CDK8 antibody, Cdk8 antibody, cdk8 antibody, cdk8.S antibody, cdk-8 antibody, CDK19 antibody
    Molecular Weight
    60 kDa
    NCBI Accession
    NP_001251
    Pathways
    Cell Division Cycle, Regulation of Lipid Metabolism by PPARalpha
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