anti-AXL antibody (AXL Receptor tyrosine Kinase) (AA 863-894)

Details for Product anti-AXL Antibody No. ABIN391877
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Synonyms JTK11, UFO, AI323647, Ark, Tyro7, Ufo
AA 863-894, C-Term
(32), (22), (15), (14), (14), (13), (13), (12), (8), (7), (5), (5), (5), (4), (4), (4), (4), (3), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
(168), (59), (47), (3)
(133), (42), (4), (2), (1)
Clonality (Clone)
Polyclonal ()
This AXL antibody is un-conjugated
(9), (9), (8), (8), (7), (6), (2), (2), (2), (2), (2), (2), (2), (2)
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(145), (88), (49), (25), (20), (19), (15), (9), (6), (5), (5), (2), (1), (1)
Pubmed 4 references available
Quantity 400 μL
Shipping to United States ( )
Availability Will be delivered in 2 to 4 Business Days
Immunogen This AXL antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 863-894 AA from the C-terminal region of human AXL.
Clone RB1483
Isotype Ig
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Alternative Name AXL (AXL Antibody Abstract)
Background AXL, a member of the AXL/UFO subfamily of Tyr protein kinases, may function as a signal transducer between specific cell types of mesodermal origin. This Type I membrane protein has transforming potential in patients with chronic myeloproliferative disorder or chronic myelocytic leukemia. The protein contains 2 putative fibronectin type III domains and 2 putative immunoglobulin-like C2-type domains.

Synonyms: Tyrosine-protein kinase receptor UFO precursor, AXL oncogene
Molecular Weight 97374 Da
Gene ID 558
UniProt P30530
Research Area Phospho-specific antibodies, Protein Modifications, Cell Structure, Cancer
Pathways RTK Signaling
Application Notes Suggested dilutions:
WB = 1:1000, IHC (p) = 1:50-100
Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Concentration 2 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.
Handling Advice Avoid freeze-thaw cycles.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots.
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-AXL antibody (AXL Receptor tyrosine Kinase) (AA 863-894) (ABIN391877) Western blot analysis of anti-AXL C-term Pab (ABIN391877) in SKBR3 cell lysate. AXL (...
Immunohistochemistry (IHC) image for anti-AXL antibody (AXL Receptor tyrosine Kinase) (AA 863-894) (ABIN391877) Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary ant...
Background publications Lee, Strunk, Spritz: "A survey of protein tyrosine kinase mRNAs expressed in normal human melanocytes." in: Oncogene, Vol. 8, Issue 12, pp. 3403-10, 1993 (PubMed).

Partanen, Mäkelä, Alitalo et al.: "Putative tyrosine kinases expressed in K-562 human leukemia cells." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 87, Issue 22, pp. 8913-7, 1991 (PubMed).

Janssen, Schulz, Steenvoorden et al.: "A novel putative tyrosine kinase receptor with oncogenic potential." in: Oncogene, Vol. 6, Issue 11, pp. 2113-20, 1991 (PubMed).

OBryan, Frye, Cogswell et al.: "axl, a transforming gene isolated from primary human myeloid leukemia cells, encodes a novel receptor tyrosine kinase." in: Molecular and cellular biology, Vol. 11, Issue 10, pp. 5016-31, 1991 (PubMed).

Catalog No. ABIN391877
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