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EPH Receptor B2 (EPHB2) (C-Term), (AA 1021-1050) antibody

Details for Product No. ABIN391920
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Antigen
Synonyms CAPB, DRT, EK5, EPHT3, ERK, Hek5, PCBC, Tyro5, Cek5, Drt, ETECK, Erk, Nuk, Prkm5, Qek5, Sek3, RGD1564232
Epitope
C-Term, AA 1021-1050
(15), (11), (7), (6), (5), (5), (4), (2), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(86), (24), (13), (13), (12), (12), (1), (1)
Host
Rabbit
(53), (28), (8), (4)
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
(4), (4), (4), (4), (3), (3), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
(71), (60), (25), (22), (15), (15), (10), (10), (1), (1), (1)
Pubmed 3 references available
Quantity 400 µL
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Catalog No. ABIN391920
291.50 $
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Immunogen This EphB2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1021-1050 AA from the C-terminal region of human EphB2.
Clone RB01652
Isotype Ig
Specificity This EphB2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1026~1055 amino acids from the C-terminal region of human EphB2.
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Alternative Name EphB2
Background Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The ligand-activated form of EphB2, which belongs to the Tyr family of protein kinases, interacts with multiple proteins, including GTPase-activating protein (RASGAP) through its SH2 domain. It binds RASGAP through the juxtamembrane tyrosines residues, and also interacts with PRKCABP and GRIP1 This type I membrane protein is expressed in brain, heart, lung, kidney, placenta, pancreas, liver and skeletal muscle. It is preferentially expressed in fetal brain. This protein contains putatively 2 fibronectin type III domains and 1 sterile alpha motif (SAM) domain.
Synonyms: Ephrin type-B receptor 2, Tyrosine-protein kinase receptor EPH-3, DRT, Receptor protein-tyrosine kinase HEK5, ERK
Molecular Weight 117506 DA
Gene ID 2048
UniProt P29323
Research Area Phospho-specific antibodies, Stem Cells, Cell Signaling, Protein Modifications, Cell Structure, Neurology
Application Notes WB = 1:1000, IHC = 1:10-50, IF = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 2 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
anti-EPH Receptor B2 (EPHB2) (C-Term), (AA 1021-1050) antibody Western blot analysis of anti-EphB2 C-term Pab (ABIN391920) in NCI-H460 cell lysate. EphB2 (arrow) was detected using purified polyclonal antibody. Secondary HRP-anti-rabbit was used for signal visualization with chemiluminescence.
anti-EPH Receptor B2 (EPHB2) (C-Term), (AA 1021-1050) antibody (2) Formalin-fixed and paraffin-embedded human breast carcinoma reacted with EphB2 Antibody (C-term) (ABIN391920), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining.
anti-EPH Receptor B2 (EPHB2) (C-Term), (AA 1021-1050) antibody (3) Formalin-fixed and paraffin-embedded human breast carcinoma tissue reacted with EphB2 antibody (C-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining.
Background publications Iwase, Tanaka, Suzuki et al.: "Identification of protein-tyrosine kinase genes preferentially expressed in embryo stomach and gastric cancer." in: Biochemical and biophysical research communications, Vol. 194, Issue 2, pp. 698-705, 1993 (PubMed).

Ikegaki, Tang, Liu et al.: "Molecular characterization and chromosomal localization of DRT (EPHT3): a developmentally regulated human protein-tyrosine kinase gene of the EPH family." in: Human molecular genetics, Vol. 4, Issue 11, pp. 2033-45, 1996 (PubMed).

Thanos, Goodwill, Bowie: "Oligomeric structure of the human EphB2 receptor SAM domain." in: Science (New York, N.Y.), Vol. 283, Issue 5403, pp. 833-6, 1999 (PubMed).

Validation Images
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