EPH Receptor B6 (EPHB6) (C-Term), (AA 990-1021) antibody

Details for Product No. ABIN391928
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Antigen
Epitope
C-Term, AA 990-1021
(13), (10), (10), (7), (7), (5), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(94), (37), (32), (18), (17)
Host
Rabbit
(70), (22), (4), (2)
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
(6), (4), (4), (4), (3), (3), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB), Immunohistochemistry (IHC)
(70), (56), (35), (21), (14), (12), (12), (4), (1), (1)
Pubmed 2 references available
Quantity 400 µL
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Catalog No. ABIN391928
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Immunogen This EphB6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 990-1021 AA from the C-terminal region of human EphB6.
Clone RB1666
Isotype Ig
Specificity This EphB6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 977~1006 amino acids from C-terminal region with histidine at postion990 of human EphB6.
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Alternative Name EphB6
Background Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. EphB6 lacks the kinase activity of most receptor tyrosine kinases and binds to ephrin-B ligands.
Synonyms: Ephrin type-B receptor 6, Tyrosine-protein kinase-defective receptor EPH-6, HEP
Molecular Weight 109272 DA
Gene ID 2051
UniProt O15197
Research Area Phospho-specific antibodies, Stem Cells, Cell Signaling, Protein Modifications, Cell Structure, Neurology
Application Notes WB = 1:1000, IHC = 1:50-100
Restrictions For Research Use only
Format Liquid
Concentration 1.11 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
anti-EPH Receptor B6 (EPHB6) (C-Term), (AA 990-1021) antibody Western blot analysis of anti-EphB6 C-term Pab (ABIN391928) in Jurkat cell lysate. EphB6 (arrow) was detected using purified polyclonal antibody. Secondary HRP-anti-rabbit was used for signal visualization with chemiluminescence.
anti-EPH Receptor B6 (EPHB6) (C-Term), (AA 990-1021) antibody (2) Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. BC = breast carcinoma. HC = hepatocarcinoma
Background publications Tang, Zhao, Robinson et al.: "Implications of EPHB6, EFNB2, and EFNB3 expressions in human neuroblastoma." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 97, Issue 20, pp. 10936-41, 2000 (PubMed).

Freywald, Sharfe, Rashotte et al.: "The EphB6 receptor inhibits JNK activation in T lymphocytes and modulates T cell receptor-mediated responses." in: The Journal of biological chemistry, Vol. 278, Issue 12, pp. 10150-6, 2003 (PubMed).

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