EPH Receptor B6 antibody

Catalog No. ABIN969479

There are 2+ publications for this product available. The Mouse Monoclonal anti-EPH Receptor B6 antibody is suitable to detect EPH Receptor B6 in samples from Human. It has been validated for WB, ELISA and IHC.

Quick Overview for EPH Receptor B6 antibody (ABIN969479)

Target: EPH Receptor B6 (EPHB6)

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This EPH Receptor B6 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Clone: 8E7H12

Product Details anti-EPH Receptor B6 Antibody

Purpose: EphB6 Antibody

Purification: Purified antibody

Immunogen: Purified recombinant fragment of EphB6 expressed in E. Coli.

Isotype: IgG1

Application Details

Application Notes: ELISA: 1/10000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified antibody in PBS containing 0.03 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

References for anti-EPH Receptor B6 antibody (ABIN969479)

Ogawa, Wada, Okada, Harada, Nakajima, Pasquale, Tsuyama: "EphB2 and ephrin-B1 expressed in the adult kidney regulate the cytoarchitecture of medullary tubule cells through Rho family GTPases." in: Journal of cell science, Vol. 119, Issue Pt 3, pp. 559-70, (2006) (PubMed).

Matsuoka, Obama, Kelly, Matsui, Nakamoto: "Biphasic functions of the kinase-defective Ephb6 receptor in cell adhesion and migration." in: The Journal of biological chemistry, Vol. 280, Issue 32, pp. 29355-63, (2005) (PubMed).

Target Details for EPH Receptor B6

Target: EPH Receptor B6 (EPHB6)

Alternative Name: EphB6

Background: EPH receptor B6 (EphB6), with 1006-amino acid protein(~ 110 kDa), belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. Eph receptors and ephrin ligands are membrane-bound cell-cell communication molecules with well-defined functions in development. EphB6 is expressed both in a variety of embryonic and adult tissues. EphB6 is a unique member in the Eph family of receptor tyrosine kinases in that its kinase domain contains several alterations in conserved amino acids and is catalytically inactive. EphB6 can both positively and negatively regulate cell adhesion and migration and tyrosine phosphorylation of the receptor by an Src family kinase acts as the molecular switch for the functional transition.

UniProt: O15197

Pathways: RTK Signaling, Hormone Transport