Fibroblast Growth Factor Receptor 2 (FGFR2) (C-Term), (AA 794-821) antibody

Details for Product No. ABIN391966
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Antigen
Synonyms
FGFR2, FGFR2IIIb, bek, bfr-1, cd332, cek3, cfd1, ect1, fgfr-2, jws, k-sam, kgfr, tk14, tk25, xfgfr2, DKFZp469H1521, BBDS, BEK, BFR-1, CD332, CEK3, CFD1, ECT1, JWS, K-SAM, KGFR, TK14, TK25, AU043015, A ... show more
FGFR2, FGFR2IIIb, bek, bfr-1, cd332, cek3, cfd1, ect1, fgfr-2, jws, k-sam, kgfr, tk14, tk25, xfgfr2, DKFZp469H1521, BBDS, BEK, BFR-1, CD332, CEK3, CFD1, ECT1, JWS, K-SAM, KGFR, TK14, TK25, AU043015, AW556123, Bek, Fgfr-2, Fgfr-7, Fgfr7, KGFRTr, svs, FGF-R, fgfr72IIIb, FGFR, fc56c05, wu:fc56c05 show less
Epitope
C-Term, AA 794-821
(24), (18), (14), (12), (6), (6), (6), (5), (4), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(150), (43), (36), (3), (2)
Host
Rabbit
(127), (24), (4), (1)
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
(5), (5), (5), (4), (4), (4), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB), Immunohistochemistry (IHC), Flow Cytometry (FACS), Immunofluorescence (IF)
(118), (71), (46), (41), (40), (27), (17), (10), (7), (2)
Pubmed 5 references available
Quantity 400 μL
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Catalog No. ABIN391966
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Immunogen This FGFR2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 794-821 AA from the C-terminal region of human FGFR2.
Clone RB1569
Isotype Ig
Specificity This FGFR2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 792~821 amino acids from the C-terminal region of human FGFR2.
Predicted Reactivity Mouse (Murine)
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Alternative Name FGFR2
Background FGFR2 is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member is a high-affinity receptor for acidic, basic and/or keratinocyte growth factor, depending on the isoform. Mutations in the gene are associated with many craniosynostotic syndromes and bone malformations. The genomic organization of the gene encompasses 20 exons. Alternative splicing in multiple exons, including those encoding the Ig-like domains, the transmembrane region and the carboxyl terminus, results in varied isoforms which differ in structure and specificity. Isoform 1 has equal affinity for aFGF and bFGF but does not bind KGF.
Synonyms: fibroblast growth factor receptor 2
Molecular Weight 92025 DA
Gene ID 2263
UniProt P21802
Research Area Phospho-specific antibodies, Cell Signaling, Protein Modifications, Cell Structure, Cell Cycle
Application Notes WB = 1:1000, IHC = 1:50-100, FACS = 1:10-50, IF = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 1.3 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
anti-Fibroblast Growth Factor Receptor 2 (FGFR2) (C-Term), (AA 794-821) antibody Western blot analysis of anti-hFGFR2-C808 Pab (ABIN391966) in 293 cell line lysates transiently transfected with the FGFR2 gene (2 µg/lane). FGFR2 (arrow) was detected using the purified polyclonal antibody.
anti-Fibroblast Growth Factor Receptor 2 (FGFR2) (C-Term), (AA 794-821) antibody (2) Western blot analysis of anti-FGFR2 Pab (ABIN391966) in NCI-H460 cell lysate. FGFR2 (arrow) was detected using purified polyclonal antibody. Secondary HRP-anti-rabbit was used for signal visualization with chemiluminescence.
anti-Fibroblast Growth Factor Receptor 2 (FGFR2) (C-Term), (AA 794-821) antibody (3) Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. BC = breast carcinoma. HC = hepatocarcinoma
Background publications Katoh, Katoh: "FGFR2 and WDR11 are neighboring oncogene and tumor suppressor gene on human chromosome 10q26." in: International journal of oncology, Vol. 22, Issue 5, pp. 1155-9, 2003 (PubMed).

Katoh, Katoh: "Recombination cluster around FGFR2-WDR11-HTPAPL locus on human chromosome 10q26." in: International journal of molecular medicine, Vol. 11, Issue 5, pp. 579-83, 2003 (PubMed).

Fomenkov, Huang, Topaloglu et al.: "P63 alpha mutations lead to aberrant splicing of keratinocyte growth factor receptor in the Hay-Wells syndrome." in: The Journal of biological chemistry, Vol. 278, Issue 26, pp. 23906-14, 2003 (PubMed).

Goriely, McVean, Röjmyr et al.: "Evidence for selective advantage of pathogenic FGFR2 mutations in the male germ line." in: Science (New York, N.Y.), Vol. 301, Issue 5633, pp. 643-6, 2003 (PubMed).

Freeman, Gangula, Welm et al.: "Conditional activation of fibroblast growth factor receptor (FGFR) 1, but not FGFR2, in prostate cancer cells leads to increased osteopontin induction, extracellular signal-regulated kinase activation, and in vivo proliferation." in: Cancer research, Vol. 63, Issue 19, pp. 6237-43, 2003 (PubMed).

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