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Details for Product No. ABIN391966

Fibroblast Growth Factor Receptor 2 (FGFR2) (C-Term), (AA 794-821) antibody

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BBDS, BEK, BFR-1, CD332, CEK3, CFD1, ECT1, JWS, K-SAM, KGFR, TK14, TK25, AU043015, AW556123, Bek, Fgfr-2, Fgfr-7, Fgfr7, KGFRTr, svs, cek3, FGF-R, FGFR2IIIb, fgfr72IIIb, FGFR, xfgfr2, fc56c05, fgfr-2, ... show more
»Alternatives C-Term, AA 794-821
»Alternatives Human
»Alternatives Rabbit
Clonality (Clone) Polyclonal ()
»Alternatives Un-conjugated
»Alternatives Western Blotting (WB), Immunohistochemistry (IHC), Flow Cytometry (FACS), Immunofluorescence (IF)
Pubmed 5 references available
Catalog no. ABIN391966
Quantity 400 µL
291.50 $   Plus shipping costs $45.00
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Immunogen This FGFR2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 794-821 AA from the C-terminal region of human FGFR2.
Clone RB1569
Isotype Ig
Specificity This FGFR2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 792~821 amino acids from the C-terminal region of human FGFR2.
Predicted Reactivity Mouse (Murine)
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Alternative Name FGFR2
Background FGFR2 is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member is a high-affinity receptor for acidic, basic and/or keratinocyte growth factor, depending on the isoform. Mutations in the gene are associated with many craniosynostotic syndromes and bone malformations. The genomic organization of the gene encompasses 20 exons. Alternative splicing in multiple exons, including those encoding the Ig-like domains, the transmembrane region and the carboxyl terminus, results in varied isoforms which differ in structure and specificity. Isoform 1 has equal affinity for aFGF and bFGF but does not bind KGF.
Synonyms: fibroblast growth factor receptor 2
Molecular Weight 92025 DA
Gene ID 2263
UniProt P21802
Research Area Phospho-specific antibodies, Cell Signaling, Protein Modifications, Cell Structure, Cell Cycle
Application Notes Recommend dilutions: WB : 1:1000,IHC : 1:50-100,FC : 1:10-50,IF : 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 1.3 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Background publications Katoh, Katoh: "FGFR2 and WDR11 are neighboring oncogene and tumor suppressor gene on human chromosome 10q26." in: International journal of oncology, Vol. 22, Issue 5, pp. 1155-9, 2003 (PubMed).

Katoh, Katoh: "Recombination cluster around FGFR2-WDR11-HTPAPL locus on human chromosome 10q26." in: International journal of molecular medicine, Vol. 11, Issue 5, pp. 579-83, 2003 (PubMed).

Fomenkov, Huang, Topaloglu et al.: "P63 alpha mutations lead to aberrant splicing of keratinocyte growth factor receptor in the Hay-Wells syndrome." in: The Journal of biological chemistry, Vol. 278, Issue 26, pp. 23906-14, 2003 (PubMed).

Goriely, McVean, Röjmyr et al.: "Evidence for selective advantage of pathogenic FGFR2 mutations in the male germ line." in: Science (New York, N.Y.), Vol. 301, Issue 5633, pp. 643-6, 2003 (PubMed).

Freeman, Gangula, Welm et al.: "Conditional activation of fibroblast growth factor receptor (FGFR) 1, but not FGFR2, in prostate cancer cells leads to increased osteopontin induction, extracellular signal-regulated kinase activation, and in vivo proliferation." in: Cancer research, Vol. 63, Issue 19, pp. 6237-43, 2003 (PubMed).

Alternatives for antigen "Fibroblast Growth Factor Receptor 2 (FGFR2)", type "Antibodies"
Hosts (90), (25), (3), (2)
Reactivities (116), (41), (31), (2), (1), (1), (1)
Applications (89), (45), (34), (26), (23), (22), (10), (7), (2), (2), (1)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (11), (10), (6), (6), (5), (4), (2), (1), (1), (1), (1), (1)