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FGFR2 antibody (AA 7-37)

FGFR2 Reactivity: Human, Mouse, Rat, Primate FACS, IF, IHC, ELISA, WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN3030951
$592.75
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  • Target See all FGFR2 Antibodies
    FGFR2 (Fibroblast Growth Factor Receptor 2 (FGFR2))
    Binding Specificity
    • 8
    • 8
    • 5
    • 5
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 7-37
    Reactivity
    • 72
    • 44
    • 23
    • 6
    • 5
    • 4
    • 4
    • 4
    • 4
    • 4
    • 3
    • 3
    • 2
    • 1
    Human, Mouse, Rat, Primate
    Host
    • 69
    • 3
    Rabbit
    Clonality
    • 59
    • 13
    Polyclonal
    Conjugate
    • 39
    • 7
    • 5
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 1
    This FGFR2 antibody is un-conjugated
    Application
    • 35
    • 20
    • 19
    • 11
    • 10
    • 7
    • 7
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    Flow Cytometry (FACS), Immunofluorescence (IF), Immunohistochemistry (IHC), ELISA, Western Blotting (WB)
    Purification
    Purified
    Immunogen
    A portion of amino acids 7-37 from the human protein was used as the immunogen for this FGFR2 antibody.
    Isotype
    Ig Fraction
  • Application Notes
    Titration of the FGFR2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. IHC (Paraffin): 1:25,Immunofluorescence: 1:25,Western blot: 1:1000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    In 1X PBS, pH 7.4, with 0.09 % sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Aliquot the FGFR2 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
  • Target
    FGFR2 (Fibroblast Growth Factor Receptor 2 (FGFR2))
    Alternative Name
    FGFR2 (FGFR2 Products)
    Synonyms
    FGFR2 antibody, FGFR2IIIb antibody, bek antibody, bfr-1 antibody, cd332 antibody, cek3 antibody, cfd1 antibody, ect1 antibody, fgfr-2 antibody, jws antibody, k-sam antibody, kgfr antibody, tk14 antibody, tk25 antibody, xfgfr2 antibody, DKFZp469H1521 antibody, BBDS antibody, BEK antibody, BFR-1 antibody, CD332 antibody, CEK3 antibody, CFD1 antibody, ECT1 antibody, JWS antibody, K-SAM antibody, KGFR antibody, TK14 antibody, TK25 antibody, AU043015 antibody, AW556123 antibody, Bek antibody, Fgfr-2 antibody, Fgfr-7 antibody, Fgfr7 antibody, KGFRTr antibody, svs antibody, FGF-R antibody, fgfr72IIIb antibody, FGFR antibody, fc56c05 antibody, wu:fc56c05 antibody, fibroblast growth factor receptor 2 antibody, fibroblast growth factor receptor 2 L homeolog antibody, FGFR2 antibody, LOC100084641 antibody, fgfr2 antibody, Fgfr2 antibody, fgfr2.L antibody
    Background
    FGFR2 is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member is a high-affinity receptor for acidic, basic and/or keratinocyte growth factor, depending on the isoform. Mutations in the gene are associated with many craniosynostotic syndromes and bone malformations. The genomic organization of the gene encompasses 20 exons. Alternative splicing in multiple exons, including those encoding the Ig-like domains, the transmembrane region and the carboxyl terminus, results in varied isoforms which differ in structure and specificity. Isoform 1 has equal affinity for aFGF and bFGF but does not bind KGF.
    UniProt
    P21802
    Pathways
    RTK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development, Growth Factor Binding
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