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Details for Product No. ABIN391968

Fibroblast Growth Factor Receptor 2 (FGFR2) antibody

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Antigen
Synonyms
BBDS, BEK, BFR-1, CD332, CEK3, CFD1, ECT1, JWS, K-SAM, KGFR, TK14, TK25, AU043015, AW556123, Bek, Fgfr-2, Fgfr-7, Fgfr7, KGFRTr, svs, cek3, FGF-R, FGFR2IIIb, fgfr72IIIb, FGFR, xfgfr2, fc56c05, fgfr-2, ... show more
Reactivity
»Alternatives Human
Host
»Alternatives Rabbit
Clonality (Clone) Polyclonal ()
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Flow Cytometry (FACS)
Pubmed 3 references available
Catalog no. ABIN391968
Quantity 400 µL
Price
291.50 $   Plus shipping costs $45.00
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Immunogen This FGFR2 antibody is generated from rabbits immunized with a his tag recombinant protein of human FGFR2.
Clone RB17696
Isotype Ig
Specificity This FGFR2 antibody is generated from rabbits immunized with a his tag recombinant protein of human FGFR2.
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Alternative Name FGFR2
Background FGFR2 is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member is a high-affinity receptor for acidic, basic and/or keratinocyte growth factor, depending on the isoform. Mutations in FGFR2 gene are associated with Crouzon syndrome, Pfeiffer syndrome, Craniosynostosis, Apert syndrome, Jackson-Weiss syndrome, Beare-Stevenson cutis gyrata syndrome, Saethre-Chotzen syndrome, and syndromic craniosynostosis.
Synonyms: Fibroblast growth factor receptor 2, Keratinocyte growth factor receptor 2, CD332, BEK, KGFR, KSAM
Molecular Weight 92025 DA
Gene ID 2263
UniProt P21802
Research Area Protein Modifications, Cell Structure, Cell Cycle
Application Notes Recommend dilutions: WB : 1:1000,IHC : 1:10-50,IF : 1:10-50,FC : 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 2 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Background publications Rutland, Pulleyn, Reardon et al.: "Identical mutations in the FGFR2 gene cause both Pfeiffer and Crouzon syndrome phenotypes." in: Nature genetics, Vol. 9, Issue 2, pp. 173-6, 1995 (PubMed).

Park, Meyers, Li et al.: "Novel FGFR2 mutations in Crouzon and Jackson-Weiss syndromes show allelic heterogeneity and phenotypic variability." in: Human molecular genetics, Vol. 4, Issue 7, pp. 1229-33, 1996 (PubMed).

McGillivray, Savarirayan, Cox et al.: "Familial scaphocephaly syndrome caused by a novel mutation in the FGFR2 tyrosine kinase domain." in: Journal of medical genetics, Vol. 42, Issue 8, pp. 656-62, 2005 (PubMed).

Alternatives for antigen "Fibroblast Growth Factor Receptor 2 (FGFR2)", type "Antibodies"
Hosts (90), (25), (3), (2)
Reactivities (116), (41), (31), (2), (1), (1), (1)
Applications (89), (45), (34), (26), (23), (22), (10), (7), (2), (2), (1)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (12), (10), (6), (6), (5), (4), (2), (2), (1), (1), (1), (1)
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