Fibroblast Growth Factor Receptor 2 (FGFR2) antibody

Details for Product No. ABIN391968
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Antigen
Synonyms
FGFR2, FGFR2IIIb, bek, bfr-1, cd332, cek3, cfd1, ect1, fgfr-2, jws, k-sam, kgfr, tk14, tk25, xfgfr2, DKFZp469H1521, BBDS, BEK, BFR-1, CD332, CEK3, CFD1, ECT1, JWS, K-SAM, KGFR, TK14, TK25, AU043015, A ... show more
FGFR2, FGFR2IIIb, bek, bfr-1, cd332, cek3, cfd1, ect1, fgfr-2, jws, k-sam, kgfr, tk14, tk25, xfgfr2, DKFZp469H1521, BBDS, BEK, BFR-1, CD332, CEK3, CFD1, ECT1, JWS, K-SAM, KGFR, TK14, TK25, AU043015, AW556123, Bek, Fgfr-2, Fgfr-7, Fgfr7, KGFRTr, svs, FGF-R, fgfr72IIIb, FGFR, fc56c05, wu:fc56c05 show less
Reactivity
Human
(150), (43), (36), (3), (2)
Host
Rabbit
(127), (24), (4), (1)
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
(5), (5), (5), (4), (4), (4), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Flow Cytometry (FACS)
(118), (71), (46), (41), (40), (27), (17), (10), (7), (2)
Pubmed 3 references available
Quantity 400 μL
Options
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Catalog No. ABIN391968
291.50 $
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Immunogen This FGFR2 antibody is generated from rabbits immunized with a his tag recombinant protein of human FGFR2.
Clone RB17696
Isotype Ig
Specificity This FGFR2 antibody is generated from rabbits immunized with a his tag recombinant protein of human FGFR2.
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Alternative Name FGFR2
Background FGFR2 is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member is a high-affinity receptor for acidic, basic and/or keratinocyte growth factor, depending on the isoform. Mutations in FGFR2 gene are associated with Crouzon syndrome, Pfeiffer syndrome, Craniosynostosis, Apert syndrome, Jackson-Weiss syndrome, Beare-Stevenson cutis gyrata syndrome, Saethre-Chotzen syndrome, and syndromic craniosynostosis.
Synonyms: Fibroblast growth factor receptor 2, Keratinocyte growth factor receptor 2, CD332, BEK, KGFR, KSAM
Molecular Weight 92025 DA
Gene ID 2263
UniProt P21802
Research Area Protein Modifications, Cell Structure, Cell Cycle
Application Notes WB = 1:1000, IHC = 1:10-50, IF = 1:10-50, FACS = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 2 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
anti-Fibroblast Growth Factor Receptor 2 (FGFR2) antibody Western blot analysis of FGFR2 Antibody (ABIN391968) in NCI-H460 cell line lysates (35 µg/lane). SFGFR2 (arrow) was detected using the purified polyclonal antibody.
anti-Fibroblast Growth Factor Receptor 2 (FGFR2) antibody (2) Western blot analysis of FGFR2 (arrow) using rabbit polyclonal FGFR2 Antibody (ABIN391968). 293 cell lysates (2 µg/lane) either nontransfected (Lane 1) or transiently transfected with the FGFR2 gene (Lane 2) (Origene Technologies).
anti-Fibroblast Growth Factor Receptor 2 (FGFR2) antibody (3) Formalin-fixed and paraffin-embedded human lung carcinoma with FGFR2 Antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining.
Background publications Rutland, Pulleyn, Reardon et al.: "Identical mutations in the FGFR2 gene cause both Pfeiffer and Crouzon syndrome phenotypes." in: Nature genetics, Vol. 9, Issue 2, pp. 173-6, 1995 (PubMed).

Park, Meyers, Li et al.: "Novel FGFR2 mutations in Crouzon and Jackson-Weiss syndromes show allelic heterogeneity and phenotypic variability." in: Human molecular genetics, Vol. 4, Issue 7, pp. 1229-33, 1996 (PubMed).

McGillivray, Savarirayan, Cox et al.: "Familial scaphocephaly syndrome caused by a novel mutation in the FGFR2 tyrosine kinase domain." in: Journal of medical genetics, Vol. 42, Issue 8, pp. 656-62, 2005 (PubMed).

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