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ROR2 antibody (N-Term)

ROR2 Reactivity: Human WB, FACS, IHC (p) Host: Rabbit Polyclonal RB01507-01508 unconjugated
Catalog No. ABIN392044
  • Target See all ROR2 Antibodies
    ROR2 (Receptor Tyrosine Kinase-Like Orphan Receptor 2 (ROR2))
    Binding Specificity
    • 12
    • 9
    • 7
    • 7
    • 5
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 19-50, N-Term
    Reactivity
    • 74
    • 27
    • 25
    • 1
    • 1
    • 1
    • 1
    Human
    Host
    • 68
    • 9
    Rabbit
    Clonality
    • 66
    • 11
    Polyclonal
    Conjugate
    • 37
    • 6
    • 6
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    This ROR2 antibody is un-conjugated
    Application
    • 51
    • 35
    • 30
    • 15
    • 7
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Purification
    This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
    Immunogen
    This ROR2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 19-50 amino acids from the N-terminal region of human ROR2.
    Clone
    RB01507-01508
    Isotype
    Ig Fraction
    Top Product
    Discover our top product ROR2 Primary Antibody
  • Application Notes
    WB: 1:1000. IHC-P: 1:10~50. FC: 1:10~50
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Storage Comment
    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
    Expiry Date
    6 months
  • Wu, Xiong, Wang, Miao, Liu, Li, Zou, Liu, Zhao, Yang: "Comparative study of ROR2 and WNT5a expression in squamous/adenosquamous carcinoma and adenocarcinoma of the gallbladder." in: World journal of gastroenterology, Vol. 23, Issue 14, pp. 2601-2612, (2018) (PubMed).

    Ma, Henry, Llamosas, Higgins, Daniels, Hesson, Hawkins, Ward, Ford: "Validation of specificity of antibodies for immunohistochemistry: the case of ROR2." in: Virchows Archiv : an international journal of pathology, (2016) (PubMed).

    OConnell, Fiori, Xu, Carter, Frank, Camilli, French, Dissanayake, Indig, Bernier, Taub, Hewitt, Weeraratna: "The orphan tyrosine kinase receptor, ROR2, mediates Wnt5A signaling in metastatic melanoma." in: Oncogene, Vol. 29, Issue 1, pp. 34-44, (2010) (PubMed).

  • Target
    ROR2 (Receptor Tyrosine Kinase-Like Orphan Receptor 2 (ROR2))
    Alternative Name
    ROR2 (ROR2 Products)
    Synonyms
    BDB antibody, BDB1 antibody, NTRKR2 antibody, Ntrkr2 antibody, mRor2 antibody, ROR2 antibody, bdb antibody, bdb1 antibody, Xror2 antibody, ntrkr2 antibody, MGC97773 antibody, LOC100219935 antibody, ror2 antibody, xror2 antibody, receptor tyrosine kinase like orphan receptor 2 antibody, receptor tyrosine kinase-like orphan receptor 2 antibody, receptor tyrosine kinase like orphan receptor 2 L homeolog antibody, ROR2 antibody, Ror2 antibody, ror2 antibody, ror2.L antibody
    Background
    ROR2 is a tyrosine-protein kinase receptor which may be involved in the early formation of the chondrocytes. It seems to be required for cartilage and growth plate development. This Type I membrane protein is expressed at high levels during early embryonic development. The expression levels drop strongly around day 16 and there are only very low levels in adult tissues. Defects in ROR2 are a cause of brachydactyly type B1 (BDB1). BDB1 is an autosomal dominant skeletal disorder characterized by hypoplasia/aplasia of distal phalanges and nails. In BDB1 the middle phalanges are short but in addition the terminal phalanges are rudimentary or absent. Both fingers and toes are affected. The thumbs and big toes are usually deformed. Defects in ROR2 are a cause of recessive Robinow syndrome (RRS). RRS is an autosomal disorder characterized by skeletal dysplasia with generalized limb bone shortening, segmental defects of the spine, brachydactyly and a dysmorphic facial appearance. The protein contains 1 frizzled (FZ) domain, 1 immunoglobulin-like C2-type domain, and 1 kringle domain.
    Molecular Weight
    104757
    Gene ID
    4920
    NCBI Accession
    NP_004551
    UniProt
    Q01974
    Pathways
    RTK Signaling, WNT Signaling
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