Receptor Tyrosine Kinase-Like Orphan Receptor 2 (ROR2) (N-Term), (AA 19-50) antibody

Details for Product No. ABIN392044
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Antigen
Synonyms ROR2, bdb, bdb1, Xror2, ntrkr2, MGC97773, LOC100219935, BDB, BDB1, NTRKR2, Ntrkr2, mRor2
Epitope
N-Term, AA 19-50
(11), (11), (5), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(50), (2), (2)
Host
Rabbit
(41), (9)
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
(3), (3), (3), (2), (2), (2)
Application
Western Blotting (WB), Immunohistochemistry (IHC), Flow Cytometry (FACS)
(38), (27), (22), (14), (7), (3)
Pubmed 5 references available
Quantity 400 µL
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Catalog No. ABIN392044
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Immunogen This ROR2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 19-50 AA from the N-terminal region of human ROR2.
Clone RB01507-01508
Isotype Ig
Specificity This ROR2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 27~57 amino acids from the N-terminal region of human ROR2.
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Alternative Name ROR2
Background ROR2 is a tyrosine-protein kinase receptor which may be involved in the early formation of the chondrocytes. It seems to be required for cartilage and growth plate development. This Type I membrane protein is expressed at high levels during early embryonic development. The expression levels drop strongly around day 16 and there are only very low levels in adult tissues. Defects in ROR2 are a cause of brachydactyly type B1 (BDB1). BDB1 is an autosomal dominant skeletal disorder characterized by hypoplasia/aplasia of distal phalanges and nails. In BDB1 the middle phalanges are short but in addition the terminal phalanges are rudimentary or absent. Both fingers and toes are affected. The thumbs and big toes are usually deformed. Defects in ROR2 are a cause of recessive Robinow syndrome (RRS). RRS is an autosomal disorder characterized by skeletal dysplasia with generalized limb bone shortening, segmental defects of the spine, brachydactyly and a dysmorphic facial appearance. The protein contains 1 frizzled (FZ) domain, 1 immunoglobulin-like C2-type domain, and 1 kringle domain.
Synonyms: Tyrosine-protein kinase transmembrane receptor ROR2, Neurotrophic tyrosine kinase, receptor-related 2 NTRKR2
Molecular Weight 104726 Da
Gene ID 4920
UniProt Q01974
Research Area Phospho-specific antibodies, Stem Cells, Cell Signaling, Protein Modifications, Cell Structure
Application Notes WB = 1:1000, IHC = 1:10-50, FACS = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 1.57 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
anti-Receptor Tyrosine Kinase-Like Orphan Receptor 2 (ROR2) (N-Term), (AA 19-50) antibody Western blot analysis of ROR2 (arrow) using rabbit polyclonal ROR2 Antibody (N-term) (ABIN392044). 293 cell lysates (2 µg/lane) either nontransfected (Lane 1) or transiently transfected with the ROR2 gene (Lane 2) (Origene Technologies).
anti-Receptor Tyrosine Kinase-Like Orphan Receptor 2 (ROR2) (N-Term), (AA 19-50) antibody (2) Formalin-fixed and paraffin-embedded human kidney carcionma reacted with ROR2 Antibody (N-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining.
anti-Receptor Tyrosine Kinase-Like Orphan Receptor 2 (ROR2) (N-Term), (AA 19-50) antibody (3) Flow cytometric analysis of NCI-H292 cells using ROR2 Antibody (N-term)(bottom histogram) compared to a negative control cell (top histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Background publications Masiakowski, Carroll: "A novel family of cell surface receptors with tyrosine kinase-like domain." in: The Journal of biological chemistry, Vol. 267, Issue 36, pp. 26181-90, 1993 (PubMed).

Oldridge, Fortuna, Maringa et al.: "Dominant mutations in ROR2, encoding an orphan receptor tyrosine kinase, cause brachydactyly type B." in: Nature genetics, Vol. 24, Issue 3, pp. 275-8, 2000 (PubMed).

Afzal, Rajab, Fenske et al.: "Recessive Robinow syndrome, allelic to dominant brachydactyly type B, is caused by mutation of ROR2." in: Nature genetics, Vol. 25, Issue 4, pp. 419-22, 2000 (PubMed).

van Bokhoven, Celli, Kayserili et al.: "Mutation of the gene encoding the ROR2 tyrosine kinase causes autosomal recessive Robinow syndrome." in: Nature genetics, Vol. 25, Issue 4, pp. 423-6, 2000 (PubMed).

Schwabe, Tinschert, Buschow et al.: "Distinct mutations in the receptor tyrosine kinase gene ROR2 cause brachydactyly type B." in: American journal of human genetics, Vol. 67, Issue 4, pp. 822-31, 2000 (PubMed).

Validation Images
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