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ROR2 antibody (AA 19-50)

ROR2 Reactivity: Human FACS, IHC, ELISA, WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN3032442
$578.58
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  • Target See all ROR2 Antibodies
    ROR2 (Receptor Tyrosine Kinase-Like Orphan Receptor 2 (ROR2))
    Binding Specificity
    • 12
    • 11
    • 11
    • 9
    • 8
    • 7
    • 5
    • 5
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 19-50
    Reactivity
    • 97
    • 28
    • 26
    • 2
    • 2
    • 2
    • 1
    Human
    Host
    • 88
    • 11
    Rabbit
    Clonality
    • 86
    • 13
    Polyclonal
    Conjugate
    • 43
    • 9
    • 8
    • 6
    • 6
    • 6
    • 5
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    This ROR2 antibody is un-conjugated
    Application
    • 71
    • 52
    • 48
    • 19
    • 6
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    Flow Cytometry (FACS), Immunohistochemistry (IHC), ELISA, Western Blotting (WB)
    Purification
    Purified
    Immunogen
    A portion of amino acids 19-50 from the human protein was used as the immunogen for this ROR2 antibody.
    Isotype
    Ig Fraction
  • Application Notes
    Titration of the ROR2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000,IHC (Paraffin): 1:10-1:50,Flow Cytometry: 1:10-1:50
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    In 1X PBS, pH 7.4, with 0.09 % sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Aliquot the ROR2 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
  • Target
    ROR2 (Receptor Tyrosine Kinase-Like Orphan Receptor 2 (ROR2))
    Alternative Name
    ROR2 (ROR2 Products)
    Synonyms
    BDB antibody, BDB1 antibody, NTRKR2 antibody, Ntrkr2 antibody, mRor2 antibody, ROR2 antibody, bdb antibody, bdb1 antibody, Xror2 antibody, ntrkr2 antibody, MGC97773 antibody, LOC100219935 antibody, ror2 antibody, xror2 antibody, receptor tyrosine kinase like orphan receptor 2 antibody, receptor tyrosine kinase-like orphan receptor 2 antibody, receptor tyrosine kinase like orphan receptor 2 L homeolog antibody, ROR2 antibody, Ror2 antibody, ror2 antibody, ror2.L antibody
    Background
    ROR2 is a tyrosine-protein kinase receptor which may be involved in the early formation of the chondrocytes. It seems to be required for cartilage and growth plate development. This Type I membrane protein is expressed at high levels during early embryonic development. The expression levels drop strongly around day 16 and there are only very low levels in adult tissues. Defects in ROR2 are a cause of brachydactyly type B1 (BDB1). BDB1 is an autosomal dominant skeletal disorder characterized by hypoplasia/aplasia of distal phalanges and nails. In BDB1 the middle phalanges are short but in addition the terminal phalanges are rudimentary or absent. Both fingers and toes are affected. The thumbs and big toes are usually deformed. Defects in ROR2 are a cause of recessive Robinow syndrome (RRS). RRS is an autosomal disorder characterized by skeletal dysplasia with generalized limb bone shortening, segmental defects of the spine, brachydactyly and a dysmorphic facial appearance. The protein contains 1 frizzled (FZ) domain, 1 immunoglobulin-like C2-type domain, and 1 kringle domain.
    UniProt
    Q01974
    Pathways
    RTK Signaling, WNT Signaling
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