ROR2 antibody

Catalog No. ABIN6940231

The Mouse Monoclonal anti-ROR2 antibody (Clone ROR2-1911) (ABIN6940231) specifically detects ROR2 in IHC. The antibody is reactive with Human samples.

Quick Overview for ROR2 antibody (ABIN6940231)

Target: ROR2 (Receptor Tyrosine Kinase-Like Orphan Receptor 2 (ROR2))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This ROR2 antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Clone: ROR2-1911

Product Details anti-ROR2 Antibody

Purpose: ROR2 Antibody

Specificity: ROR2 (receptor tyrosine kinase-like orphan receptor 2), also known as neurotrophic tyrosine kinase receptor-related 2 (NTRKR2), is a single pass transmembrane tyrosine-protein kinase receptor. It contains a cytoplasmic tyrosine kinase domain, distally located serine-threonine-rich domains, an extracellular immunoglobulin-like domain, a cysteine-rich domain and a kringle domain. ROR2 is important for skeletal and endocrine development and is required for cartilage and growth plate development. It promotes the differentiation of osteoblasts and plays an important role in the early formation of chondrocytes. ROR2 sequesters and associates with Dlxin-1 affecting the transcriptional function of Msx-2. ROR2 also interacts with canoncial Wnt-1 and Wnt-3, regulating their signaling pathways. Defects in ROR2 can result in the autosomal dominant skeletal disorder, brachydactyly type B1, or the autosomal recessive skeletal disorder, Robinow syndrome.

Purification: 200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G.

Immunogen: Human cultured keratinocytes

Isotype: IgG

Application Details

Application Notes:

Positive Control: Human breast, pancreas, kidney or GIST.

Known Application: Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 min at RT)(Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM Citrate Buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes)Optimal dilution for a specific application should be determined.

Restrictions: For Research Use only

Handling

Concentration: 200 μg/mL

Buffer: Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Expiry Date: 24 months

Target Details for ROR2

Target: ROR2 (Receptor Tyrosine Kinase-Like Orphan Receptor 2 (ROR2))

Alternative Name: ROR2

Background:

BR, CD49 antigen-like family member B, ROR2, Collagen receptor, DX5, Glycoprotein Ia deficiency included (GPIa), Human platelet alloantigen system 5 (HPA5 included), Integrin alpha II (ITGA2), Platelet alloantigen Br(a), included, Platelet glycoprotein Ia/IIa, Platelet membrane glycoprotein Ia, VLA2,

Human breast, kidney or GIST., Pancreas

Molecular Weight: 120kDa

Gene ID: 4920, 644776, 98255

UniProt: Q01974

Pathways: RTK Signaling, WNT Signaling