TBK (AA 150-181), (Ser172) antibody

Details for Product No. ABIN392371
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Antigen
Epitope
AA 150-181, Ser172
(2)
Reactivity
Human
(2)
Host
Rabbit
(2)
Clonality (Clone)
Polyclonal ()
Application
Western Blotting (WB), Immunohistochemistry (IHC)
(2)
Pubmed 3 references available
Quantity 400 μL
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Catalog No. ABIN392371
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Immunogen This TBK antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 150-181 AA from human TBK.
Clone RB16573
Isotype Ig
Specificity This TBK antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide corresponding to amino acid residues surrounding S172 of human TBK.
Predicted Reactivity Mouse (Murine),Xenopus laevis
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Background The NF-kappa-B (NFKB) complex of proteins is inhibited by I-kappa-B (IKB) proteins, which inactivate NFKB by trapping it in the cytoplasm. Phosphorylation of serine residues on the IKB proteins by IKB kinases marks them for destruction via the ubiquitination pathway, thereby allowing activation and nuclear translocation of the NFKB complex. TKB is similar to IKB kinases and can mediate NFKB activation in response to certain growth factors. The protein can form a complex with the IKB protein TANK and TRAF2 and release the NFKB inhibition caused by TANK.
Synonyms: NAK, Serine/threonine-protein kinase TBK1, TANK-binding kinase 1, T2K, NF-kappa-B-activating kinase, TBK1
Molecular Weight 83642 DA
Gene ID 29110
NCBI Accession NP_037386
Research Area Phospho-specific antibodies, Cell Signaling, Protein Modifications, Transcription Factors, Signaling, Cell Structure
Application Notes WB = 1:1000, IHC = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
anti-TBK (AA 150-181), (Ser172) antibody Western blot analysis of anti-TBK Antibody (S172) (ABIN392371) in K562 cell line lysates (35 µg/lane). TBK1(arrow) was detected using the purified polyclonal antibody.
anti-TBK (AA 150-181), (Ser172) antibody (2) Formalin-fixed and paraffin-embedded human testis tissue reacted with TBK-pS172, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining.
Background publications Soulat, Bürckstümmer, Westermayer et al.: "The DEAD-box helicase DDX3X is a critical component of the TANK-binding kinase 1-dependent innate immune response." in: The EMBO journal, Vol. 27, Issue 15, pp. 2135-46, 2008 (PubMed).

Deng, Shi, Han et al.: "Negative regulation of virus-triggered IFN-beta signaling pathway by alternative splicing of TBK1." in: The Journal of biological chemistry, Vol. 283, Issue 51, pp. 35590-7, 2008 (PubMed).

Chessler, Ferreira, Chang et al.: "A novel IFN regulatory factor 3-dependent pathway activated by trypanosomes triggers IFN-beta in macrophages and fibroblasts." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 181, Issue 11, pp. 7917-24, 2008 (PubMed).

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