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Details for Product No. ABIN401599

Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2B (GRIN2B) (pTyr1474) antibody

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Antigen
Synonyms AW490526, GluN2B, NR2B, Nmdar2b, MRD6, NMDAR2B, hNR3, nr2b, nmdar2b
Epitope
»Alternatives pTyr1474
Reactivity
»Alternatives Human, Mouse (Murine), Rat (Rattus)
Host
»Alternatives Rabbit
Clonality Polyclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Immunocytochemistry (ICC), Immunofluorescence (IF)
Pubmed 4 references available
Catalog no. ABIN401599
Quantity 50 µg
Price
275.00 $   Plus shipping costs $45.00
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Availability Will be delivered in 6 to 8 Business Days
Immunogen Synthesized phosphopeptide derived from human NMDAR2B around the phosphorylation site of Tyr1474 (H-V-YP-E-K)
Specificity NMDAR2B (phospho-Tyr1474) antibody detects endogenous levels of NMDAR2B only when phosphorylated at Tyr1474.
Purification Affinity-chromatography
Alternative Name NMDAR2B
Background NMDA receptors are a class of ionotropic glutamate receptors. NMDA receptor channel has been shown to be involved in long term potentiation, an activity dependent increase in the efficiency of synaptic transmission thought to underlie certain types of memory and learning. NMDA receptor channels are heteromers composed of the key receptor subunit NMDAR1 (GRIN1) and 1 or more of the 4 NMDAR2 subunits: NMDAR2A (GRIN2A), NMDAR2B (GRIN2B), NMDAR2C (GRIN2C), and NMDAR2D (GRIN2D). GRIN2B may be a candidate gene for the neurodegenerative disorder dentato-rubro-pallidoluysian atrophy (DRPLA). Properties of NMDAR include modulation by glycine, inhibition by Zn2+, voltage dependent Mg2+ blockade and high Ca2+ permeability. The involvement of NMDAR in the CNS has become a focus area for neurodegenerative diseases such as Alzheimer's disease, epilepsy and ischemic neuronal cell death.
Alternate names: GRIN2B, Glutamate [NMDA] receptor subunit epsilon-2, N-methyl D-aspartate receptor subtype 2B, N-methyl-D-aspartate receptor subunit 3, NMDA Receptor 2B
Gene ID 2904
NCBI Accession NP_000825
UniProt Q13224
Research Area Neurology, Neurotransmitters, Receptors
Application Notes Immunofluorescence: 1/100 - 1/200. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 1,0 mg/mL
Buffer Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol
Preservative Sodium azide
Handling Advice Avoid repeated freezing and thawing.
Storage -20 °C
Expiry Date 12 months
Background publications Krueger, Daaka, Pitcher et al.: "The role of sequestration in G protein-coupled receptor resensitization. Regulation of beta2-adrenergic receptor dephosphorylation by vesicular acidification." in: The Journal of biological chemistry, Vol. 272, Issue 1, pp. 5-8, 1997 (PubMed).

Tingley, Ehlers, Kameyama et al.: "Characterization of protein kinase A and protein kinase C phosphorylation of the N-methyl-D-aspartate receptor NR1 subunit using phosphorylation site-specific antibodies." in: The Journal of biological chemistry, Vol. 272, Issue 8, pp. 5157-66, 1997 (PubMed).

Westphal, Tavalin, Lin et al.: "Regulation of NMDA receptors by an associated phosphatase-kinase signaling complex." in: Science (New York, N.Y.), Vol. 285, Issue 5424, pp. 93-6, 1999 (PubMed).

Liu, Murray, Jones: "Switching of NMDA receptor 2A and 2B subunits at thalamic and cortical synapses during early postnatal development." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 24, Issue 40, pp. 8885-95, 2004 (PubMed).

Alternatives for antigen "Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2B (GRIN2B)", type "Antibodies"
Hosts (285), (24), (6)
Reactivities (273), (271), (243), (139), (136), (135), (70), (17), (8), (7), (3), (3), (2), (1)
Applications (185), (90), (90), (90), (41), (37), (37), (19), (19), (10), (4), (4), (1)
Conjugates (9), (9), (9), (9), (9), (9), (9), (9), (9), (9), (9), (6), (6), (6), (6), (6)
Epitopes (38), (35), (32), (23), (23), (23), (19), (17), (9), (7), (4), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1)
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