L3MBTL1 antibody (N-Term)

Catalog No. ABIN405117

Product Details anti-L3MBTL1 Antibody

Target: L3MBTL1 (L(3)mbt-Like 1 (L3MBTL1))

Binding Specificity: N-Term

Reactivity: Human, Guinea Pig, Dog

Host: Rabbit

Clonality: Polyclonal

Conjugate: This L3MBTL1 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: RRREGHGTDS EMGQGPVRES QSSDPPALQF RISEYKPLNM AGVEQPPSPE

Predicted Reactivity: Dog: 92%, Guinea Pig: 77%, Human: 100%

Characteristics: This is a rabbit polyclonal antibody against L3MBTL. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human L3MBTL

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 772 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for L3MBTL1

Target: L3MBTL1 (L(3)mbt-Like 1 (L3MBTL1))

Alternative Name: L3MBTL (L3MBTL1 Products)

Background: L3MBTL is the homolog of a protein identified in Drosophila as a suppressor of malignant transformation of neuroblasts and ganglion-mother cells in the optic centers of the brain. L3MBTL is localized to condensed chromosomes in mitotic cells. Overexpression of this gene in a glioma cell line results in improper nuclear segregation and cytokinesis producing multinucleated cells.This gene encodes the homolog of a protein identified in Drosophila as a suppressor of malignant transformation of neuroblasts and ganglion-mother cells in the optic centers of the brain. This gene product is localized to condensed chromosomes in mitotic cells. Overexpression of this gene in a glioma cell line results in improper nuclear segregation and cytokinesis producing multinucleated cells. Alternatively spliced transcript variants encoding different isoforms have been identified.
Alias Symbols: DKFZp586P1522, FLJ41181, H-L(3)MBT, KIAA0681, L3MBTL1, dJ138B7.3, L3MBTL
Protein Interaction Partner: VCP, UBC, PCNA, MCM7, MCM6, MCM5, MCM4, MCM3, CDC45, MCM2, SETD8, TP53, HIST1H1E, L3MBTL1, ETV7, ETV6, HIST2H4A, CBX3, RB1, HIST1H1B, SETD7, CBX5,
Protein Size: 772

Molecular Weight: 86 kDa

Gene ID: 26013

NCBI Accession: NM_015478, NP_056293

UniProt: Q9Y468

Pathways: Chromatin Binding