HTRA4 antibody (Middle Region)

Catalog No. ABIN406558

This Rabbit Polyclonal antibody specifically detects HTRA4 in WB. It exhibits reactivity toward Human, Rat, Mouse, Cow, Guinea Pig, Dog, Horse, Pig and Rabbit.

Quick Overview for HTRA4 antibody (Middle Region) (ABIN406558)

Target: HTRA4 (HtrA Serine Peptidase 4 (HTRA4))

Reactivity: Human, Rat, Mouse, Cow, Guinea Pig, Dog, Horse, Pig, Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HTRA4 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-HTRA4 Antibody

Binding Specificity: Middle Region

Sequence: LKMHYPDFPD VSSGVYVCKV VEGTAAQSSG LRDHDVIVNI NGKPITTTTD

Predicted Reactivity: Cow: 86%, Dog: 93%, Guinea Pig: 86%, Horse: 92%, Human: 100%, Mouse: 86%, Pig: 93%, Rabbit: 93%, Rat: 93%

Characteristics: This is a rabbit polyclonal antibody against HTRA4. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human HTRA4

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 476 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for HTRA4

Target: HTRA4 (HtrA Serine Peptidase 4 (HTRA4))

Alternative Name: HTRA4

Background: HTRA4 is a member of the HtrA family of proteases. The protein contains a putative signal peptide, an insulin growth factor binding domain, a Kazal protease inhibitor domain, a conserved trypsin domain and a PDZ domain. Based on studies on other related family members, this enzyme may function as a secreted oligomeric chaperone protease to degrade misfolded secretory proteins. Other human HtrA proteins have been implicated in arthritis, tumor suppression, unfolded stress response, apoptosis, and aging.
Alias Symbols: FLJ90724
Protein Size: 476

Molecular Weight: 51 kDa

Gene ID: 203100

NCBI Accession: NM_153692, NP_710159

UniProt: P83105