Peripheral-Type Benzodiazepine Receptor (TSPO) (C-Term) antibody

Details for Product No. ABIN452349
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Antigen
Synonyms LOC732875, LOC100136652, LOC100280949, BZRP, TSPO, Bzrp, IBP, PBR, Tspo1, MBR, PTBZR02, Ptbzr, RATPTBZR02, BPBS, DBI, PBS, PKBS, PTBR, mDRC, pk18
Epitope
C-Term
(10), (4), (1), (1)
Reactivity
Human
(31), (21), (17), (12), (12)
Host
Goat
(19), (11), (5), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(23), (15), (10), (10), (3), (2), (1)
Pubmed 1 reference available
Quantity 0.1 mg
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Catalog No. ABIN452349
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Immunogen Peptide with sequence from the C Terminus of the protein sequence according to NP_000705.2. Genename: TSPO
Sequence c-RDNHGWRGGR RLPE
Specificity This antibody is expected to recognise one isoform of TSPO/PBR (NP_000705.2) only.
Purification Ammonium Sulphate Precipitation followed by antigen Affinity Chromatography using the immunizing peptide
Alternative Name TSPO / BZRP
Background PBR (Peripheral type Benzodiazepine Receptor) is a ubiquitous protein (18 kDa) found in most steroidogenic tissues. It is located primarily in the outer mitochondrial membrane of steroid producing tissues and is found in association with a 34 kDa voltage dependent anion channel protein (VDAC). PBR interacts with some benzodiazepines and has different affinities than its endogenous counterpart. PBR appears to be a key factor in the transport of cholesterol from the outer to the inner mitochondrial membrane to permit the initiation of steroid hormone synthesis. It is thought to be part of the mitochondrial permeability transition pore (PT) and to be involved in apoptosis. It is speculated that patients with congenital lipoid adrenal hyperplasia, who cannot make any steroids, might have a genetic lesion in BZRP. A short form, PBRS is also expressed in the same tissues, but at a level about ten times that of PBR.
Alternate names: MBR, Mitochondrial benzodiazepine receptor, PBR, PKBS, Peripheral-type benzodiazepine receptor, Translocator protein
Gene ID 706
NCBI Accession NP_000705
UniProt P30536
Application Notes Peptide ELISA: Detection Limit: 1/128000. Western blot: 0.1-0.3 µg/ml. Approx 35kDa band observed in Human Brain lysates(calculated MW of 18.8kDa according to NP_000705.2). Immunohistochemistry: 2-4 µg/ml. In paraffin embedded Human Colon shows strongcytoplasm staining of absorptive cells.
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer Tris buffered saline, pH~7.3 containing 0.02% Sodium Azide as preservative and 0.5% BSA as stabilizer
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store undiluted at 2-8°C for one month or (in aliquots) at-20°C for longer.
Expiry Date 12 months
Supplier Images
anti-Peripheral-Type Benzodiazepine Receptor (TSPO) (C-Term) antibody anti-Peripheral-Type Benzodiazepine Receptor (TSPO) (C-Term) antibody
anti-Peripheral-Type Benzodiazepine Receptor (TSPO) (C-Term) antibody (2) anti-Peripheral-Type Benzodiazepine Receptor (TSPO) (C-Term) antibody (Image 2)
Background publications Papadopoulos, Baraldi, Guilarte et al.: "Translocator protein (18kDa): new nomenclature for the peripheral-type benzodiazepine receptor based on its structure and molecular function." in: Trends in pharmacological sciences, Vol. 27, Issue 8, pp. 402-9, 2006 (PubMed).

Validation Images
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