Excision Repair Cross-Complementing Rodent Repair Deficiency, Complementation Group 8 (ERCC8) (C-Term) antibody

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Antigen
Synonyms zgc:103550, CKN1, CSA, UVSS2, Ckn1, 2410022P04Rik, 2810431L23Rik, 4631412O06Rik, B130065P18Rik, Csa
Alternatives
Epitope
C-Term
(17), (13), (12), (7), (5), (5), (4), (4), (2), (2), (1), (1), (1)
Reactivity
Human
(87), (28), (19), (4), (3), (1), (1)
Host
Rabbit
(71), (16)
Clonality
Polyclonal
Conjugate
Un-conjugated
(3), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Immunohistochemistry (IHC), Western Blotting (WB)
(73), (21), (18), (16), (12), (11), (6), (3), (3), (3), (2), (2), (1), (1)
Pubmed 1 reference available
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Quantity 50 μg
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Immunogen Synthetic peptide directed towards the C terminal of human ERCC8
Sequence QELYSGSRDC NILAWVPSLY EPVPDDDETT TKSQLNPAFE DAWSSSDEEG
Predicted Reactivity Human : 100 %, Dog : 90 %, Horse : 80 %, Rabbit : 70 %
Characteristics This is a rabbit polyclonal antibody against ERCC8. It was validated on Western Blot and immunohistochemistry.
Purification Affinity Purified
Alternative Name ERCC8 (ERCC8 Antibody Abstract)
Background ERCC8 (excision repair cross-complementing rodent repair deficiency, complementation group 8 isoform 1) is a WD repeat protein, which interacts with Cockayne syndrome type B (CSB) protein and with p44 protein, a subunit of the RNA polymerase II transcript
Molecular Weight 44 kDa
Gene ID 1161
NCBI Accession NP_000073, NM_000082
UniProt Q13216
Research Area Chromatin and Nuclear Signaling, DNA/RNA
Pathways DNA Damage Repair
Application Notes Optimal working dilutions should be determined experimentally by the investigator.
Comment

Antigen size: 396 AA

Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 50 µL of distilled water.
Concentration 1 mg/mL
Buffer PBS buffer with 2 % sucrose
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For longer periods of storage, store at -20 °C
Supplier Images
Western Blotting (WB) image for anti-Excision Repair Cross-Complementing Rodent Repair Deficiency, Complementation Group 8 (ERCC8) (C-Term) antibody (ABIN486848) WB Suggested Anti-ERCC8 Antibody Titration: 0.1-5.0ug/ml
ELISA Titer:
Immunohistochemistry (IHC) image for anti-Excision Repair Cross-Complementing Rodent Repair Deficiency, Complementation Group 8 (ERCC8) (C-Term) antibody (ABIN486848) anti-Excision Repair Cross-Complementing Rodent Repair Deficiency, Complementation Group 8 (ERCC8) (C-Term) antibody (Image 2)
Immunohistochemistry (IHC) image for anti-Excision Repair Cross-Complementing Rodent Repair Deficiency, Complementation Group 8 (ERCC8) (C-Term) antibody (ABIN486848) anti-Excision Repair Cross-Complementing Rodent Repair Deficiency, Complementation Group 8 (ERCC8) (C-Term) antibody (Image 3)
Western Blotting (WB) image for anti-Excision Repair Cross-Complementing Rodent Repair Deficiency, Complementation Group 8 (ERCC8) (C-Term) antibody (ABIN486848) Host: Rabbit
Target Name: ERCC8
Sample Tissue: Human Adult Placenta
Western Blotting (WB) image for anti-Excision Repair Cross-Complementing Rodent Repair Deficiency, Complementation Group 8 (ERCC8) (C-Term) antibody (ABIN486848) Host: Rabbit
Target Name: ERCC8
Sample Tissue: MCF7 Whole Cell lysates ...
Western Blotting (WB) image for anti-Excision Repair Cross-Complementing Rodent Repair Deficiency, Complementation Group 8 (ERCC8) (C-Term) antibody (ABIN486848) Host: Rabbit
Target Name: ERCC8
Sample Tissue: Human Fetal Lung
...
Western Blotting (WB) image for anti-Excision Repair Cross-Complementing Rodent Repair Deficiency, Complementation Group 8 (ERCC8) (C-Term) antibody (ABIN486848) Host: Rabbit
Target Name: ERCC8
Sample Tissue: Human Fetal Heart
...
Background publications Groisman, Polanowska, Kuraoka et al.: "The ubiquitin ligase activity in the DDB2 and CSA complexes is differentially regulated by the COP9 signalosome in response to DNA damage." in: Cell, Vol. 113, Issue 3, pp. 357-67, 2003 (PubMed).

Catalog No. ABIN486848
$289.00
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