TRPV5 antibody (N-Term)

Catalog No. ABIN487228

Product Details anti-TRPV5 Antibody

Target: TRPV5 (Transient Receptor Potential Cation Channel, Subfamily V, Member 5 (TRPV5))

Binding Specificity: N-Term

Reactivity: Human, Rat, Mouse, Cow, Dog, Pig, Guinea Pig, Horse, Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TRPV5 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Sequence: MLQQKRILES PLLRASKEND LSVLRQLLLD CTCDVRQRGA LGETALHIAA

Predicted Reactivity: Cow: 85%, Dog: 85%, Guinea Pig: 85%, Horse: 77%, Human: 100%, Mouse: 85%, Pig: 92%, Rabbit: 77%, Rat: 85%

Characteristics: This is a rabbit polyclonal antibody against TRPV5. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human TRPV5

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 729 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

References for anti-TRPV5 antibody (ABIN487228)

Cha, Wu, Huang: "Protein kinase C inhibits caveolae-mediated endocytosis of TRPV5." in: American journal of physiology. Renal physiology, Vol. 294, Issue 5, pp. F1212-21, (2008) (PubMed).

Target Details for TRPV5

Target: TRPV5 (Transient Receptor Potential Cation Channel, Subfamily V, Member 5 (TRPV5))

Alternative Name: TRPV5 (TRPV5 Products)

Background: TRPV5 is a member of the transient receptor family and the TrpV subfamily. TRPV5, a calcium-selective channel, has 6 transmembrane-spanning domains, multiple potential phosphorylation sites, an N-linked glycosylation site, and 5 ANK repeats. TRPV5 forms homotetramers or heterotetramers and is activated by a low internal calcium level.This gene is a member of the transient receptor family and the TrpV subfamily. The calcium-selective channel encoded by this gene has 6 transmembrane-spanning domains, multiple potential phosphorylation sites, an N-linked glycosylation site, and 5 ANK repeats. This protein forms homotetramers or heterotetramers and is activated by a low internal calcium level. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications. PRIMARYREFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-2486 AF304464.1 86-2571
Alias Symbols: CAT2, ECAC1, OTRPC3
Protein Interaction Partner: EWSR1, CALB1, S100A10, ANXA2,
Protein Size: 729

Molecular Weight: 82 kDa

Gene ID: 56302

NCBI Accession: NM_019841, NP_062815

UniProt: Q9NQA5