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Mortality Factor 4 Like 1 (MORF4L1) (N-Term) antibody

Details for Product No. ABIN487997, Supplier: Log in to see
Antigen
  • CG6363
  • DmMRG15
  • Dmel\\CG6363
  • Dmrg15
  • Mrg15
  • dMRG15
  • dMrg15
  • l(3)j6A3
  • Eaf3
  • HsT17725
  • MEAF3
  • MORFRG15
  • MRG15
  • S863-6
  • zgc:92289
  • MORF4L2
  • TEG-189
  • Tex189
  • mKIAA4002
Epitope
N-Term
17
6
6
4
3
3
1
1
1
1
1
1
Reactivity
Cow (Bovine), Dog (Canine), Human, Mouse (Murine), Rat (Rattus)
71
57
28
4
4
4
2
2
2
1
Host
Goat
58
17
6
1
Clonality
Polyclonal
Conjugate
Un-conjugated
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
Application
Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
61
35
27
15
13
9
4
2
1
1
Supplier
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Immunogen Syntehtic peptide from the N-Terminus of Human MORF4L1 (NP_006782.1, NP_996670.1) . Genename: MORF4L1
Sequence APKQDPKPKF QEG-C
Specificity This antibody recognizes MRG15 and is expected to recognise Isoform 1 (NP_006782.1) and Isoform 2 (NP_996670.1).
Cross-Reactivity (Details) Species reactivity (expected):Mouse, Rat, Porcine, Bovine.
Species reactivity (tested):Human.
Purification Affinity Chromatography
Alternative Name MRG15 (MORF4L1 Antibody Abstract)
Background MRG15 ia a component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis and DNA repair.Synonyms: FWP006, HSPC008, HSPC061, MORF-related gene 15 protein, MORF4L1, MRG15, MSL3-1 protein, Mortality factor 4-like protein 1, PP368, Transcription factor-like protein MRG15
Molecular Weight 37.2 kDa (Mouse NP_077751.1).
Gene ID 10933
NCBI Accession NP_006782
UniProt Q9UBU8
Research Area Cancer, Cell Cycle, Transcription Factors, DNA/RNA
Pathways
Application Notes Peptide ELISA: 1/64000. Western blot: Preliminary experiments gave an approx 40 kDa band in Human Liver lysatesand an approx 100 kDa band in Human Heart lysates at 1 μg/mL. Please note that currentlywe cannot find an explanation in the literature for the bands we observe given thecalculated size of 37.0 kDda according to NP_006782.1. Immunohistochemistry on paraffin sections: Human Uterus shows nuclear staining in theepithelial cells of the endometrial glands. Recommended concentration: 2 - 4 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Concentration 0.5 mg/mL
Buffer Tris saline, pH ~7.3, 0.02 % Sodium Azide, 0.5 % BSA
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.
Supplier Images
 image for anti-Mortality Factor 4 Like 1 (MORF4L1) (N-Term) antibody (ABIN487997) anti-Mortality Factor 4 Like 1 (MORF4L1) (N-Term) antibody
Background publications Pardo, Leung, Lucchesi et al.: "MRG15, a novel chromodomain protein, is present in two distinct multiprotein complexes involved in transcriptional activation." in: The Journal of biological chemistry, Vol. 277, Issue 52, pp. 50860-6, 2002 (PubMed).