Activation-Induced Cytidine Deaminase (AICDA) (C-Term) antibody

Details for Product No. ABIN499233
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Antigen
Synonyms AID, AICDA, aid, arp2, cda2, higm2, xlaid, ARP2, CDA2, HIGM2, Aid, Arp2, 4921510D23Rik, AA409782, D6Ertd746e
Epitope
C-Term
(19), (18), (12), (12), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human, Mouse (Murine)
(99), (60), (33), (25), (5), (4), (2)
Host
Rabbit
(73), (23), (10), (8)
Clonality
Polyclonal
Conjugate
Un-conjugated
(4), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2)
Application
ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF), Western Blotting (WB)
(84), (53), (19), (15), (14), (12), (7), (5), (2), (1), (1)
Pubmed 5 references available
Quantity 0.1 mg
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Catalog No. ABIN499233
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Immunogen A Peptide corresponding to 14 amino acids near the carboxy-terminus of Human AID
Isotype IgG
Specificity This antibody recognizes AID (C-term).
Purification Affinity chromatography purified via peptide column
Alternative Name AICDA / AID
Background Activation-induced cytidine deaminase (AID) was initially discovered as a homolog of the apolipoprotein B RNA-editing cytidine deaminase 1 (APOBEC1) that showed cytidine deaminase properties in stimulated B cell lines (1). It is necessary for somatic hypermutation and class switch recombination in B cells (2), but inappropriate or dysregulated expression AID is often found in tumors and B cell neoplasms (2,3). Although it is structurally and functionally similar to the APOBEC proteins (reviewed in 4), it appears unlikely that AID deaminates dC to dU residues in HIV cDNA as does APOBEC3G (5).
Alternate names: Activation-induced cytidine deaminase, Cytidine aminohydrolase
Gene ID 57379
NCBI Accession NP_065712
UniProt Q9GZX7
Application Notes ELISA. Western Blot: AID antibody can be used for detection of AID at 1 - 2 μg/ml. Whole cell lysatefrom Ramos cells can be used as positive control. Immunocytochemistry. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Buffer PBS containing 0.02% Sodium Azide as preservative
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Expiry Date 12 months
Background publications Chu, Wahl, Orgel: "Derivatization of unprotected polynucleotides." in: Nucleic acids research, Vol. 11, Issue 18, pp. 6513-29, 1983 (PubMed).

Muramatsu, Sankaranand, Anant et al.: "Specific expression of activation-induced cytidine deaminase (AID), a novel member of the RNA-editing deaminase family in germinal center B cells." in: The Journal of biological chemistry, Vol. 274, Issue 26, pp. 18470-6, 1999 (PubMed).

Muramatsu, Kinoshita, Fagarasan et al.: "Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme." in: Cell, Vol. 102, Issue 5, pp. 553-63, 2000 (PubMed).

Sheehy, Gaddis, Choi et al.: "Isolation of a human gene that inhibits HIV-1 infection and is suppressed by the viral Vif protein." in: Nature, Vol. 418, Issue 6898, pp. 646-50, 2002 (PubMed).

Greeve, Philipsen, Krause et al.: "Expression of activation-induced cytidine deaminase in human B-cell non-Hodgkin lymphomas." in: Blood, Vol. 101, Issue 9, pp. 3574-80, 2003 (PubMed).

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