AICDA antibody (AA 101-198)

Catalog No. ABIN872554

This Rabbit Polyclonal antibody specifically detects AICDA in WB, IHC (p), IHC (fro), IF (cc) and IF (p). It exhibits reactivity toward Human.It has been mentioned in 1 publication

Quick Overview for AICDA antibody (AA 101-198) (ABIN872554)

Target: AICDA (Activation-Induced Cytidine Deaminase (AICDA))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This AICDA antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Product Details anti-AICDA Antibody

Binding Specificity: AA 101-198

Purpose: AICDA Polyclonal Antibody

Cross-Reactivity: Human

Predicted Reactivity: Mouse,Rat

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human AICDA

Isotype: IgG

Application Details

Application Notes: WB(1:500-1000),

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4C. Store at -20C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

References for anti-AICDA antibody (ABIN872554)

Demberg, Mohanram, Musich, Brocca-Cofano, McKinnon, Venzon, Robert-Guroff: "Loss of marginal zone B-cells in SHIVSF162P4 challenged rhesus macaques despite control of viremia to low or undetectable levels in chronic infection." in: Virology, Vol. 484, pp. 323-333, (2015) (PubMed).

Target Details for AICDA

Target: AICDA (Activation-Induced Cytidine Deaminase (AICDA))

Alternative Name: AICDA

Background:

Synonyms: AID, ARP2, CDA2, HIGM2, HEL-S-284, Single-stranded DNA cytosine deaminase, Activation-induced cytidine deaminase, Cytidine aminohydrolase, AICDA

Background: Single-stranded DNA-specific cytidine deaminase. Involved in somatic hypermutation, gene conversion, and class-switch recombination in B-lymphocytes. Required for several crucial steps of B-cell terminal differentiation necessary for efficient antibody responses. May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation.

Gene ID: 57379

UniProt: Q9GZX7

Pathways: Cellular Response to Molecule of Bacterial Origin, Regulation of Actin Filament Polymerization, Production of Molecular Mediator of Immune Response