CADPS2 antibody (Center)

Catalog No. ABIN499527

This anti-CADPS2 antibody is a Rabbit Polyclonal antibody detecting CADPS2 in WB, EIA and IHC (p). Suitable for Human, Rat and Mouse.

Quick Overview for CADPS2 antibody (Center) (ABIN499527)

Target: CADPS2 (Ca++-Dependent Secretion Activator 2 (CADPS2))

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CADPS2 antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-CADPS2 Antibody

Binding Specificity: Center

Specificity: This antibody reacts to CAPS2.

Purification: Affinity chromatography purified via peptide column

Immunogen: CAPS2 antibody was raised against a 19 amino acid peptide near the center of the human CAPS2.

Isotype: IgG

Application Details

Application Notes: ELISA. Western Blot: CAPS2 antibody can be used for detection of CAPS2 at 0.5 - 1 μg/mL. Immunohistochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Buffer: PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Store the antibody undiluted at 2-8 °C.

Target Details for CADPS2

Target: CADPS2 (Ca++-Dependent Secretion Activator 2 (CADPS2))

Alternative Name: CADPS2 / CAPS2

Background: CAPS2 and the related protein CAPS1 encode novel neural/endocrine-specific cytosolic and peripheral membrane proteins. Both are essential components of the synaptic vesicle priming machinery and are required for the Ca2+-regulated exocytosis of secretory vesicles, CAPS-deficient neurons contain no or very few fusion competent synaptic vesicles, causing a selective impairment of fast phasic transmitter release. Like CAPS1, numerous isoforms of CAPS2 are known to exist. These isoforms show distinct expression patterns in the brain. For example, CAPS2b showed high expression in the developing cerebellum. Furthermore, one version of CAPS2 mRNA that lacks exon 3 is detected in some autistic patients, suggesting that the differential expression pattern of CAPS2 is involved in neuronal development. This CAPS2 antibody is predicted to be specific to CAPS2 and not recognize CAPS1.Synonyms: Calcium-dependent activator protein for secretion 2, Calcium-dependent secretion activator 2, KIAA1591

Gene ID: 93664

NCBI Accession: NP_060424

UniProt: Q86UW7

Pathways: Synaptic Vesicle Exocytosis