C1QTNF1 antibody (N-Term)

Catalog No. ABIN499660

Product Details anti-C1QTNF1 Antibody

Target: C1QTNF1 (C1q and Tumor Necrosis Factor Related Protein 1 (C1QTNF1))

Binding Specificity: N-Term

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This C1QTNF1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Specificity: CTRP1 (NT) antibody was raised against a 15 amino acid peptide from near the amino-terminus of human CTRP1.

Purification: Affinity chromatography purified via peptide column

Immunogen: Human CTRP1 / G protein coupled receptor interacting protein 1 / GIP (N-Terminus) Peptide

Isotype: IgG

Application Details

Application Notes: ELISA. Western Blot: CTRP1 antibody can be used for the detection of CTRP1 at 1 μg/mL. Theseproteins are often highly modified post-translationally and migrate in SDS-PAGE atpositions other than their predicted size. Immunohistochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Buffer: PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Store the antibody undiluted at 2-8 °C.

Target Details for C1QTNF1

Target: C1QTNF1 (C1q and Tumor Necrosis Factor Related Protein 1 (C1QTNF1))

Alternative Name: C1QTNF1 (C1QTNF1 Products)

Background: Adipose tissue of an organism plays a major role in regulating physiologic and pathologic processes such as metabolism and immunity by producing and secreting a variety of bioactive molecules termed adipokines (reviewed in 1). One highly conserved family of adipokines is adiponectin/ACRP30 and its structural and functional paralogs, the C1q/tumor necrosis factor-related proteins (CTRPs) 1-7 (2). Unlike adiponectin, which is expressed exclusively by differentiated adipocytes, the CTRPs are expressed in a wide variety of tissues (3). These proteins are thought to act mainly on liver and muscle tissue to control glucose and lipid metabolism. An analysis of the crystal structure of adiponectin revealed a structural and evolutionary link between TNF and C1q-containing proteins, suggesting that these proteins arose from a common ancestral innate immunity gene (4). In obese (ob/ob) mice, RT-PCR analysis showed that mCTRP1 transcripts are seen at substantially higher levels in adipose tissues compared to those of normal mice (3).Synonyms: CTRP1, Complement C1q tumor necrosis factor-related protein 1, G protein-coupled receptor-interacting protein, GIP

Gene ID: 114897

NCBI Accession: NP_940995

UniProt: Q9BXJ1