IL27 antibody (N-Term)

Catalog No. ABIN500000

The Rabbit Polyclonal anti-IL27 antibody has been validated for WB, EIA and IF. It is suitable to detect IL27 in samples from Human and Mouse.

Quick Overview for IL27 antibody (N-Term) (ABIN500000)

Target: IL27 (Interleukin-27 Subunit alpha (IL27))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IL27 antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA), Immunofluorescence (IF)

Product Details anti-IL27 Antibody

Binding Specificity: N-Term

Specificity: This antibody reacts to IL-27.

Purification: Affinity chromatography purified via peptide column

Immunogen: Affinity chromatography purified via peptide column

Isotype: IgG

Application Details

Application Notes: ELISA. Western Blot: 2 - 4 μg/mL. Immunocytochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Buffer: PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Target Details for IL27

Target: IL27 (Interleukin-27 Subunit alpha (IL27))

Alternative Name: Interleukin-27 / IL27A

Background: Like interleukin-23 (IL-23), IL-27 is a recently discovered member of the IL-6/IL-12 family of proinflammatory and immunoregulatory cytokines. It exists as a heterodimer composed of the p40-related protein EBI3 and an IL-12 p35-related protein termed p28. IL-27 is produced after activation by antigen-presenting cells and induces proliferation of naive but not memory CD4+ T-cells. It acts by binding to its receptor WSX-1 and gp130 which results in the activation of a Jak/STAT signaling cascade, suggesting the IL-27 is involved in the regulation of immune processes. It has been suggested that IL-27 can also be used as a therapeutic agent against cancer as it can also induce tumor-specific anti-tumor activity mediated through CD8+ T-cells, IFN-γ, and T-bet.Synonyms: IL-27 subunit alpha, IL-30, IL27-A, IL30, Interleukin-30, p28

Gene ID: 246778

NCBI Accession: NP_663634

UniProt: Q8NEV9