TBC1D1 antibody (C-Term)

Catalog No. ABIN500871

Product Details anti-TBC1D1 Antibody

Target: TBC1D1 (TBC1 (Tre-2/USP6, BUB2, Cdc16) Domain Family, Member 1 (TBC1D1))

Binding Specificity: C-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TBC1D1 antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Specificity: This antibody detects TBC1D1 at C-term.

Cross-Reactivity (Details): Species reactivity (tested):Human

Purification: Peptide afiinity chromatography

Immunogen: TBC1D1 antibody was raised against a 22 amino acid peptide from near the carboxy terminus of human TBC1D1.

Isotype: IgG

Application Details

Application Notes: ELISA. Western blot.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Buffer: PBS containing 0.02 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.

Target Details for TBC1D1

Target: TBC1D1 (TBC1 (Tre-2/USP6, BUB2, Cdc16) Domain Family, Member 1 (TBC1D1))

Alternative Name: TBC1D1 (TBC1D1 Products)

Background: TBC1D1 is the founding member of a family of proteins sharing a 180- to 200-amino acid TBC domain and presumed to have a role in regulating cell growth and differentiation. These proteins share significant homology with TRE2/USP6, yeast Bub2, and CDC16. TBC1D1 and TBC1D4 (AS160) have been demonstrated to be Rab GAPs (GTPase-activating proteins) that link upstream to Akt and phosphoinositide 3-kinase and downstream to Rabs involved in trafficking of GLUT4 vesicles. TBC1D1 regulates insulin-mediated GLUT4 translocation through its GAP activity, and is a likely Akt substrate. Mutations in the Tbc1d1 gene lead to some cases of severe human obesity.Synonyms: KIAA1108, TBC1 domain family member 1

Gene ID: 23216

NCBI Accession: NP_055988