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TARDBP antibody (Center)

TARDBP Reactivity: Human, Mouse, Rat WB, IF, EIA Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN500883
  • Target See all TARDBP Antibodies
    TARDBP (TAR DNA Binding Protein (TARDBP))
    Binding Specificity
    • 15
    • 12
    • 11
    • 9
    • 8
    • 7
    • 7
    • 7
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Center
    Reactivity
    • 100
    • 58
    • 58
    • 13
    • 8
    • 8
    • 7
    • 6
    • 6
    • 5
    • 5
    • 4
    • 3
    • 2
    • 1
    • 1
    Human, Mouse, Rat
    Host
    • 102
    • 14
    • 1
    Rabbit
    Clonality
    • 93
    • 24
    Polyclonal
    Conjugate
    • 64
    • 7
    • 5
    • 5
    • 5
    • 5
    • 5
    • 5
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    This TARDBP antibody is un-conjugated
    Application
    • 85
    • 47
    • 34
    • 31
    • 21
    • 18
    • 14
    • 13
    • 13
    • 7
    • 4
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF), Enzyme Immunoassay (EIA)
    Specificity
    At least two isoforms are known to exist for this protein, this TDP43 antibody only recongizes the longer of the two isoforms.
    Cross-Reactivity (Details)
    Species reactivity (tested):Human, mouse, rat
    Purification
    Peptide affinity chromatography
    Immunogen
    TDP43 antibody was raised against a 18 amino acid peptide from near the center of human TDP43.
    Isotype
    IgG
    Top Product
    Discover our top product TARDBP Primary Antibody
  • Application Notes
    ELISA. Western blot: 0.5 - 1 μg/mL. Immunoflourescence.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Concentration
    1.0 mg/mL
    Buffer
    PBS containing 0.02 % sodium azide
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freezing and thawing.
    Storage
    -20 °C
    Storage Comment
    Store the antibody (in aliquots) at -20 °C.
  • Target
    TARDBP (TAR DNA Binding Protein (TARDBP))
    Alternative Name
    TARDBP (TARDBP Products)
    Synonyms
    TARDBP antibody, TDP43 antibody, DKFZp459I2127 antibody, tardbp antibody, ALS10 antibody, TDP-43 antibody, 1190002A23Rik antibody, C85084 antibody, Tdp43 antibody, wu:fb77f02 antibody, wu:fc52g10 antibody, TAR DNA binding protein antibody, Tardbp protein antibody, TAR DNA binding protein L homeolog antibody, TAR DNA-binding protein 43-like antibody, TARDBP antibody, tardbp antibody, tardbp.L antibody, Tardbp antibody, LOC100621383 antibody
    Background
    TDP43 was initially identified as a novel cellular protein that bound to HIV-1 virus TAR DNA sequence motifs and acts a transcriptional repressor to the HIV-1 LTR. Later experiments revealed that TDP43 also regulates the splicing of exon 9 of the cystic fibrosis transmembrane conductance regular (CFTR), most likely through the association with the UG repeats at the 3' splice site. A hyperphosphorylated, ubiquitinated, and cleaved form of TDP43 known as pathologic TDP43 is the major disease protein in ubiquitin-positive, tau-, and alpha-synuclein-negative frontotemporal dementia (FLTD-U). TDP43 is not related to TRBP1, and RNA binding protein that binds HIV-1 TAR RNA sequences. At least two isoforms are known to exist for this protein, this TDP43 antibody only recongizes the longer of the two isoforms.Synonyms: TAR DNA-binding protein 43, TDP-43, TDP43
    Gene ID
    23435
    NCBI Accession
    NP_031401
    Pathways
    Positive Regulation of Peptide Hormone Secretion
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