TAR DNA Binding Protein (TARDBP) (Center) antibody

Details for Product No. ABIN500883
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Antigen
Synonyms ALS10, TDP-43, Tdp43, C85084, 1190002A23Rik, wu:fb77f02, wu:fc52g10, TARDBP, TDP43, DKFZp459I2127, tardbp
Epitope
Center
(17), (15), (9), (7), (7), (7), (3), (2), (2), (2), (1), (1)
Reactivity
Human, Mouse (Murine), Rat (Rattus)
(109), (63), (49), (29), (16), (14), (14), (12), (5), (3), (1)
Host
Rabbit
(84), (25), (5), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(3), (3), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF), Western Blotting (WB)
(97), (46), (23), (20), (18), (18), (10), (3), (2), (2), (1)
Pubmed 3 references available
Catalog no. ABIN500883
Quantity 0.1 mg
Price
401.50 $   Plus shipping costs $45.00
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Immunogen TDP43 antibody was raised against a 18 amino acid peptide from near the center of human TDP43.
Isotype IgG
Specificity At least two isoforms are known to exist for this protein, this TDP43 antibody only recongizes the longer of the two isoforms.
Purification Peptide affinity chromatography
Alternative Name TARDBP
Background TDP43 was initially identified as a novel cellular protein that bound to HIV-1 virus TAR DNA sequence motifs and acts a transcriptional repressor to the HIV-1 LTR. Later experiments revealed that TDP43 also regulates the splicing of exon 9 of the cystic fibrosis transmembrane conductance regular (CFTR), most likely through the association with the UG repeats at the 3’ splice site. A hyperphosphorylated, ubiquitinated, and cleaved form of TDP43 known as pathologic TDP43 is the major disease protein in ubiquitin-positive, tau-, and alpha-synuclein-negative frontotemporal dementia (FLTD-U). TDP43 is not related to TRBP1, and RNA binding protein that binds HIV-1 TAR RNA sequences. At least two isoforms are known to exist for this protein, this TDP43 antibody only recongizes the longer of the two isoforms.
Alternate names: TAR DNA-binding protein 43, TDP-43, TDP43
Gene ID 23435
NCBI Accession NP_031401
Research Area Chromatin and Nuclear Signaling, Transcription Factors, DNA/RNA, Hormones, Cytokines
Application Notes ELISA. Western blot: 0.5 – 1 μg/ml. Immunoflourescence. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 1.0 mg/mL
Buffer PBS containing 0.02% sodium azide
Preservative Sodium azide
Handling Advice Avoid repeated freezing and thawing.
Storage -20 °C
Storage Comment Store the antibody (in aliquots) at -20°C.
Expiry Date 12 months
Background publications Ou, Wu, Harrich et al.: "Cloning and characterization of a novel cellular protein, TDP-43, that binds to human immunodeficiency virus type 1 TAR DNA sequence motifs." in: Journal of virology, Vol. 69, Issue 6, pp. 3584-96, 1995 (PubMed).

Buratti, Dörk, Zuccato et al.: "Nuclear factor TDP-43 and SR proteins promote in vitro and in vivo CFTR exon 9 skipping." in: The EMBO journal, Vol. 20, Issue 7, pp. 1774-84, 2001 (PubMed).

Neumann, Sampathu, Kwong et al.: "Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis." in: Science (New York, N.Y.), Vol. 314, Issue 5796, pp. 130-3, 2006 (PubMed).

Hosts (84), (25), (5), (1)
Reactivities (109), (63), (49), (29), (16), (14), (14), (12), (5), (3), (1)
Applications (97), (46), (23), (20), (18), (18), (10), (3), (2), (2), (1)
Conjugates (3), (3), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (17), (15), (9), (7), (7), (7), (3), (2), (2), (2), (1), (1)
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