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PCSK4 antibody (N-Term)

PCSK4 Reactivity: Human, Mouse, Rat, Cow, Dog, Guinea Pig, Pig WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN504511
  • Target See all PCSK4 Antibodies
    PCSK4 (Proprotein Convertase Subtilisin/kexin Type 4 (PCSK4))
    Binding Specificity
    • 15
    • 11
    • 8
    • 6
    • 2
    • 1
    • 1
    N-Term
    Reactivity
    • 34
    • 21
    • 5
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Human, Mouse, Rat, Cow, Dog, Guinea Pig, Pig
    Host
    • 37
    • 1
    Rabbit
    Clonality
    • 38
    Polyclonal
    Conjugate
    • 14
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This PCSK4 antibody is un-conjugated
    Application
    • 38
    • 18
    • 13
    • 13
    • 3
    • 3
    • 1
    Western Blotting (WB)
    Sequence
    VSSWAVQVSQ GNREVERLAR KFGFVNLGPI FPDGQYFHLR HRGVVQQSLT
    Predicted Reactivity
    Cow: 100%, Dog: 100%, Guinea Pig: 93%, Human: 100%, Mouse: 86%, Pig: 100%, Rat: 93%
    Characteristics
    This is a rabbit polyclonal antibody against PCSK4. It was validated on Western Blot using a cell lysate as a positive control.
    Purification
    Affinity Purified
    Immunogen
    The immunogen is a synthetic peptide directed towards the N terminal region of human PCSK4
    Top Product
    Discover our top product PCSK4 Primary Antibody
  • Application Notes
    Optimal working dilutions should be determined experimentally by the investigator.
    Comment

    Antigen size: 755 AA

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freeze-thaw cycles.
    Storage
    -20 °C
    Storage Comment
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Target
    PCSK4 (Proprotein Convertase Subtilisin/kexin Type 4 (PCSK4))
    Alternative Name
    PCSK4 (PCSK4 Products)
    Synonyms
    PC4 antibody, SPC5 antibody, AI647044 antibody, L21221 antibody, NEC 3 antibody, NEC3 antibody, PCSK4 antibody, pc4 antibody, spc5 antibody, MGC146505 antibody, pcsk4 antibody, proprotein convertase subtilisin/kexin type 4 antibody, proprotein convertase subtilisin/kexin type 4 L homeolog antibody, PCSK4 antibody, Pcsk4 antibody, pcsk4 antibody, pcsk4.L antibody
    Background
    PCSK4 is involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. PCSK4 plays a role in transcriptional coactivation. PCSK4 may be involved in stabilizing the multiprotein transcription complex.Proprotein convertases, including PCSK4, are calcium-dependent serine proteases related to bacterial subtilisins and to yeast kexin. These enzymes process precursor proteins to their active forms by selective cleavage of the polypeptide at sites following paired basic amino acids. In mammals, this family comprises PC1 (MIM 162150), PC2 (MIM 162151), PC4, PC5 (MIM 600488), furin (FUR, MIM 136950), and PACE4 (MIM 167405). Substrates for these enzymes range from prohormones to precursors for growth factors to cell surface receptors and viral surface glycoproteins (Cao et al., 2001 [PubMed 11776387]).[supplied by OMIM]. PRIMARYREFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-31 AC027307.5 80201-80231 c 32-257 AY358963.1 32-257 258-655 AK057235.1 452-849 656-2528 AY358963.1 656-2528 2529-2606 AL043305.1 210-287 2607-2674 AA453604.1 1-68 c
    Alias Symbols: DKFZp434B217, MGC34749, PC4, SPC5
    Protein Interaction Partner: IGF2,
    Protein Size: 755
    Molecular Weight
    83 kDa
    Gene ID
    54760
    NCBI Accession
    NM_017573, NP_060043
    UniProt
    Q6UW60
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