PCSK4 antibody (N-Term)

Catalog No. ABIN3032335

Product Details anti-PCSK4 Antibody

Target: PCSK4 (Proprotein Convertase Subtilisin/kexin Type 4 (PCSK4))

Binding Specificity: N-Term

Reactivity: Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PCSK4 antibody is un-conjugated

Application: Western Blotting (WB)

Purification: Antigen affinity

Immunogen: An amino acid sequence from the N-terminus of mouse Proprotein convertase 4 (DPWFSKQWYMNKEIQQD) was used as the immunogen for this Proprotein Convertase 4 antibody.

Isotype: IgG

Application Details

Application Notes: The stated application concentrations are suggested starting amounts. Titration of the Proprotein Convertase 4 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL

Restrictions: For Research Use only

Handling

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: -20 °C

Storage Comment: After reconstitution, the Proprotein Convertase 4 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Target Details for PCSK4

Target: PCSK4 (Proprotein Convertase Subtilisin/kexin Type 4 (PCSK4))

Alternative Name: Proprotein Convertase 4 (PCSK4 Products)

Synonyms: PC4 antibody, SPC5 antibody, AI647044 antibody, L21221 antibody, NEC 3 antibody, NEC3 antibody, PCSK4 antibody, pc4 antibody, spc5 antibody, MGC146505 antibody, pcsk4 antibody, proprotein convertase subtilisin/kexin type 4 antibody, proprotein convertase subtilisin/kexin type 4 L homeolog antibody, PCSK4 antibody, Pcsk4 antibody, pcsk4 antibody, pcsk4.L antibody

Background: Proprotein Convertase, Subtilisin/Kexin-Type, 4, is an enzyme that in humans is encoded by the PCSK4 gene. The gene was mapped to mouse chromosome 10, close to the adipsin locus and near the gene encoding anti-mullerian hormone. Qiu et al.(2005) found that aberrant processing of pro-IGF2 may be a cause of IUGR. PCSK4 cleaved pro-IGF2 to generate the intermediate processed form, IGF2(1-102). Mature IGF2(1-67), likely resulting from further processing by carboxypeptidases, is capable of activating invasive trophoblast cells through AKT phosphorylation. Inhibition of the protein by a PCSK4-specific inhibitor blocked pro-IGF2 processing and reduced trophoblast cell migration.

UniProt: P29121