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TAR DNA Binding Protein (TARDBP) (AA 1-260), (full length) antibody

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Synonyms TARDBP, TDP43, DKFZp459I2127, tardbp, ALS10, TDP-43, 1190002A23Rik, C85084, Tdp43, wu:fb77f02, wu:fc52g10
AA 1-260, full length
(29), (22), (16), (14), (13), (12), (12), (10), (7), (4), (3), (3), (3), (3), (2), (1), (1), (1), (1)
(167), (70), (55), (10), (8), (8), (7), (6), (5), (4), (3), (2), (1), (1)
(124), (35), (15), (1)
Clonality (Clone)
Monoclonal ()
(7), (6), (5), (3), (3), (3), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunoprecipitation (IP), RNA Interference (RNAi), Western Blotting (WB)
(154), (75), (54), (41), (36), (22), (11), (11), (7), (5), (4), (2), (2), (1)
Pubmed 21 references available
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Quantity 100 μg
Shipping to United States ( )
Availability Will be delivered in 9 Business Day(s)
Immunogen TARDBP (AAH01487.1, 1 a.a. ~ 260 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Clone 2E2-D3
Isotype IgG1 kappa
Cross-Reactivity Human
Alternative Name TARDBP (TARDBP Antibody Abstract)
Background Full Gene Name: TAR DNA binding protein
Synonyms: ALS10,TDP-43
Gene ID 23435
NCBI Accession NP_031401, NM_007375
Research Area Chromatin and Nuclear Signaling, Transcription Factors, DNA/RNA, Hormones, Cytokines
Application Notes Optimal working dilution should be determined by the investigator.

Product Quality tested by: Antibody Reactive Against Recombinant Protein.

Restrictions For Research Use only
Buffer In 1x PBS, pH 7.4
Handling Advice Aliquot to avoid repeated freezing and thawing.
Storage -20 °C
Storage Comment Store at -20 °C or lower. Aliquot to avoid repeated freezing and thawing.
Supplier Images
Immunostaining (IS) image for anti-TAR DNA Binding Protein (TARDBP) (AA 1-260), (full length) antibody (ABIN565080) Immunoperoxidase of monoclonal antibody to TARDBP on formalin-fixed paraffin-embedded...
Immunofluorescence (IF) image for anti-TAR DNA Binding Protein (TARDBP) (AA 1-260), (full length) antibody (ABIN565080) Immunofluorescence of monoclonal antibody to TARDBP on HeLa cell. [antibody concentra...
Western Blotting (WB) image for anti-TAR DNA Binding Protein (TARDBP) (AA 1-260), (full length) antibody (ABIN565080) TARDBP monoclonal antibody (M01), clone 2E2-D3 Western Blot analysis of TARDBP expres...
Western Blotting (WB) image for anti-TAR DNA Binding Protein (TARDBP) (AA 1-260), (full length) antibody (ABIN565080) Western blot analysis of TARDBP over-expressed 293 cell line, cotransfected with TARD...
Western Blotting (WB) image for anti-TAR DNA Binding Protein (TARDBP) (AA 1-260), (full length) antibody (ABIN565080) Western Blot analysis of TARDBP expression in transfected 293T cell line by TARDBP mo...
Immunoprecipitation (IP) image for anti-TAR DNA Binding Protein (TARDBP) (AA 1-260), (full length) antibody (ABIN565080) Immunoprecipitation of TARDBP transfected lysate using anti-TARDBP monoclonal antibod...
ELISA image for anti-TAR DNA Binding Protein (TARDBP) (AA 1-260), (full length) antibody (ABIN565080) Detection limit for recombinant GST tagged TARDBP is 0.3 ng/ml as a capture antibody.
Image no. 8 for anti-TAR DNA Binding Protein (TARDBP) (AA 1-260), (full length) antibody (ABIN565080) Western Blot detection against Immunogen (54.34 KDa) .
Product cited in: Rosenbohm, Buckert, Gerischer et al.: "Early diagnosis of cardiac involvement in idiopathic inflammatory myopathy by cardiac magnetic resonance tomography." in: Journal of neurology, Vol. 262, Issue 4, pp. 949-56, 2015 (PubMed).

Saldi, Ash, Wilson et al.: "TDP-1, the Caenorhabditis elegans ortholog of TDP-43, limits the accumulation of double-stranded RNA." in: The EMBO journal, Vol. 33, Issue 24, pp. 2947-66, 2014 (PubMed).

Alafuzoff, Pikkarainen, Neumann et al.: "Neuropathological assessments of the pathology in frontotemporal lobar degeneration with TDP43-positive inclusions: an inter-laboratory study by the BrainNet Europe consortium. ..." in: Journal of neural transmission (Vienna, Austria : 1996), 2014 (PubMed).

Kara, Kiely, Proukakis et al.: "A 6.4 Mb duplication of the ?-synuclein locus causing frontotemporal dementia and Parkinsonism: phenotype-genotype correlations." in: JAMA neurology, Vol. 71, Issue 9, pp. 1162-71, 2014 (PubMed).

Robinson, Thompson, Weedon et al.: "No interaction between tau and TDP-43 pathologies in either frontotemporal lobar degeneration or motor neurone disease." in: Neuropathology and applied neurobiology, Vol. 40, Issue 7, pp. 844-54, 2014 (PubMed).

Wenqiang, Lonskaya, Hebron et al.: "Parkin-mediated reduction of nuclear and soluble TDP-43 reverses behavioral decline in symptomatic mice." in: Human molecular genetics, Vol. 23, Issue 18, pp. 4960-9, 2014 (PubMed).

Hans, Fiesel, Strong et al.: "UBE2E ubiquitin-conjugating enzymes and ubiquitin isopeptidase Y regulate TDP-43 protein ubiquitination." in: The Journal of biological chemistry, Vol. 289, Issue 27, pp. 19164-79, 2014 (PubMed).

Ohta, Tremblay, Schneider et al.: "Interaction of transactive response DNA binding protein 43 with nuclear factor ?B in mild cognitive impairment with episodic memory deficits." in: Acta neuropathologica communications, Vol. 2, Issue 1, pp. 37, 2014 (PubMed).

Carlomagno, Zhang, Davis et al.: "Casein kinase II induced polymerization of soluble TDP-43 into filaments is inhibited by heat shock proteins." in: PLoS ONE, Vol. 9, Issue 3, pp. e90452, 2014 (PubMed).

Araki, Minegishi, Motoki et al.: "Disease-associated mutations of TDP-43 promote turnover of the protein through the proteasomal pathway." in: Molecular neurobiology, Vol. 50, Issue 3, pp. 1049-58, 2014 (PubMed).

Cortese, Plagnol, Brady et al.: "Widespread RNA metabolism impairment in sporadic inclusion body myositis TDP43-proteinopathy." in: Neurobiology of aging, Vol. 35, Issue 6, pp. 1491-8, 2014 (PubMed).

De Marco, Lomartire, Mandili et al.: "Reduced cellular Ca(2+) availability enhances TDP-43 cleavage by apoptotic caspases." in: Biochimica et biophysica acta, Vol. 1843, Issue 4, pp. 725-34, 2014 (PubMed).

Gelpi, Navarro-Otano, Tolosa et al.: "Multiple organ involvement by alpha-synuclein pathology in Lewy body disorders." in: Movement disorders : official journal of the Movement Disorder Society, Vol. 29, Issue 8, pp. 1010-8, 2014 (PubMed).

Yan, Wang, Wei et al.: "TDP-43 causes differential pathology in neuronal versus glial cells in the mouse brain." in: Human molecular genetics, Vol. 23, Issue 10, pp. 2678-93, 2014 (PubMed).

Balasa, Gelpi, Rey et al.: "Clinical and neuropathological variability in clinically isolated central nervous system Whipple's disease." in: Brain pathology (Zurich, Switzerland), Vol. 24, Issue 3, pp. 230-8, 2014 (PubMed).

Walker, Soo, Sundaramoorthy et al.: "ALS-associated TDP-43 induces endoplasmic reticulum stress, which drives cytoplasmic TDP-43 accumulation and stress granule formation." in: PLoS ONE, Vol. 8, Issue 11, pp. e81170, 2013 (PubMed).

Suárez-Calvet, Dols-Icardo, Lladó et al.: "Plasma phosphorylated TDP-43 levels are elevated in patients with frontotemporal dementia carrying a C9orf72 repeat expansion or a GRN mutation." in: Journal of neurology, neurosurgery, and psychiatry, Vol. 85, Issue 6, pp. 684-91, 2014 (PubMed).

Hebron, Chen, Miessau et al.: "Parkin reverses TDP-43-induced cell death and failure of amino acid homeostasis." in: Journal of neurochemistry, Vol. 129, Issue 2, pp. 350-61, 2014 (PubMed).

Iovino, Pfisterer, Holton et al.: "The novel MAPT mutation K298E: mechanisms of mutant tau toxicity, brain pathology and tau expression in induced fibroblast-derived neurons." in: Acta neuropathologica, Vol. 127, Issue 2, pp. 283-95, 2014 (PubMed).

Lashley, Rohrer, Mahoney et al.: "A pathogenic progranulin mutation and C9orf72 repeat expansion in a family with frontotemporal dementia." in: Neuropathology and applied neurobiology, Vol. 40, Issue 4, pp. 502-13, 2014 (PubMed).

Maruyama, Morino, Ito et al.: "Mutations of optineurin in amyotrophic lateral sclerosis. ..." in: Nature, Vol. 465, Issue 7295, pp. 223-6, 2010 (PubMed).

Catalog No. ABIN565080
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