Tumor Necrosis Factor Receptor Superfamily, Member 8 (TNFRSF8) antibody (APC)

Details for Product No. ABIN614241
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Antigen
Synonyms CD30, TNFRSF8, Cd30, D1S166E, Ki, Ki-1
Reactivity
Human
(154), (80), (1)
Host
Mouse
(119), (56), (34), (23), (2), (2)
Clonality (Clone)
Monoclonal ()
Conjugate
APC
(36), (21), (17), (5), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Flow Cytometry (FACS)
(145), (59), (45), (35), (20), (14), (11), (10), (9), (8), (6), (2), (1), (1), (1)
Pubmed 9 references available
Quantity 100 tests
Shipping to United States (Change)
Availability Will be delivered in 6 to 8 Business Days
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN614241
412.50 $
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Clone MEM-268
Isotype IgG
Specificity This antibody recognizes extracellular part of CD30 (Ki-1 antigen), a 105 kDa single chain glycoprotein expressed on Hodgkin's and Reed-Sternberg cells, it is also found in Burkitt's lymphomas, virus-infected T and B lymphocytes, and on normal B and T lymphocytes after activation (T lymphocytes that produce Th2-type cytokines and on CD4+/CD8+ T lymphocytes that co-express CD45RO and the IL4 receptor).
Purification Size-exclusion chromatography
Alternative Name CD30
Background CD30 is a type I transmembrane glycoprotein of the TNF receptor superfamily. CD30 was originally identified as a cell surface antigen of Hodgkins and Reed-Sternberg cells using monoclonal antibody Ki-1. The ligand for CD30 is CD30L (CD153). The binding of CD30 to CD30L mediates pleiotropic effects including cell proliferation, activation, differentiation, and apoptotic cell death. CD30 has a critical role in the pathophysiology of Hodgkin's disease and other CD30+ lymphomas. CD30 acts as a costimulatory molecule in thymic negative selection. In addition to its expression on Hodgkin's and Reed-Sternberg cells, CD30 is also found in some non-Hodgkin's lymphomas (including Burkitt's lymphomas), virus-infected T and B cells, and on normal T and B cells after activation. In T cells, CD30 expression is present on a subset of T cells that produce Th2-type cytokines and on CD4+/CD8+ thymocytes that co-express CD45RO and the IL4 receptor. Soluble form of CD30 (sCD30) serves as a marker reflecting Th2 immune response.Synonyms: CD30L receptor, D1S166E, KI-1 antigen, Lymphocyte activation antigen CD30, TNFRSF8, Tumor necrosis factor receptor superfamily member 8
Gene ID 943
Research Area Cancer, Innate Immunity, Cytokines, CD Antigens, Surface Receptors of Immune Cells
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Buffer Phosphate buffered saline (PBS) containing 15 mM sodium azide and 0.2 % (w/v) high-grade protease free Bovine Serum Albumin (BSA) as a stabilizing agent
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Background publications Lamarque, Rodière, Pasqual et al.: "[Mammotomography, a new technic of breast examination]." in: La Nouvelle presse médicale, Vol. 5, Issue 43, pp. 2933-8, 1977 (PubMed).

Blazar, Levy, Mak et al.: "CD30/CD30 ligand (CD153) interaction regulates CD4+ T cell-mediated graft-versus-host disease." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 173, Issue 5, pp. 2933-41, 2004 (PubMed).

Kennedy, Willis, Armitage: "Deciphering CD30 ligand biology and its role in humoral immunity." in: Immunology, Vol. 118, Issue 2, pp. 143-52, 2006 (PubMed).

Fischer, Harvima, Carvalho et al.: "Mast cell CD30 ligand is upregulated in cutaneous inflammation and mediates degranulation-independent chemokine secretion." in: The Journal of clinical investigation, Vol. 116, Issue 10, pp. 2748-56, 2006 (PubMed).

Polte, Behrendt, Hansen: "Direct evidence for a critical role of CD30 in the development of allergic asthma." in: The Journal of allergy and clinical immunology, Vol. 118, Issue 4, pp. 942-8, 2006 (PubMed).

Zeiser, Nguyen, Hou et al.: "Early CD30 signaling is critical for adoptively transferred CD4+CD25+ regulatory T cells in prevention of acute graft-versus-host disease." in: Blood, Vol. 109, Issue 5, pp. 2225-33, 2007 (PubMed).

Wright, Rumble, Duckett: "CD30 activates both the canonical and alternative NF-kappaB pathways in anaplastic large cell lymphoma cells." in: The Journal of biological chemistry, Vol. 282, Issue 14, pp. 10252-62, 2007 (PubMed).

Bekiaris, Withers, Glanville et al.: "Role of CD30 in B/T segregation in the spleen." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 179, Issue 11, pp. 7535-43, 2007 (PubMed).

Pavlov, Martins, Delgado: "Development and validation of a fluorescent microsphere immunoassay for soluble CD30 testing." in: Clinical and vaccine immunology : CVI, Vol. 16, Issue 9, pp. 1327-31, 2009 (PubMed).

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