Tumor Necrosis Factor Receptor Superfamily, Member 8 (TNFRSF8) antibody

Details for Product No. ABIN614243
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Antigen
Synonyms CD30, TNFRSF8, Cd30, D1S166E, Ki, Ki-1
Reactivity
Human
(183), (121), (15), (1), (1), (1)
Host
Mouse
(140), (64), (54), (38), (2), (2)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(44), (30), (22), (9), (5), (3), (2), (2), (2), (2), (2), (2), (2), (2)
Application
Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
(190), (59), (59), (50), (39), (20), (18), (10), (8), (6), (5), (3), (2), (2), (1), (1)
Pubmed 9 references available
Quantity 0.1 mg
Shipping to United States ( )
Availability Will be delivered in 6 to 8 Business Days
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Clone MEM-268
Isotype IgG
Specificity The antibody MEM-268 recognizes extracellular part of CD30 (Ki-1 antigen), a 105 kDa single chain glycoprotein expressed on Hodgkin's and Reed-Sternberg cells, it is also found in Burkitt's lymphomas, virus-infected T and B lymphocytes, and on normal B and T lymphocytes after activation (T lymphocytes that produce Th2-type cytokines and on CD4+/CD8+ T lymphocytes that co-express CD45RO and the IL4 receptor).
Cross-Reactivity (Details) Species reactivity (tested):Human
Purification Affinity Chromatography on Protein A
Alternative Name CD30 (TNFRSF8 Antibody Abstract)
Background CD30 is a type I transmembrane glycoprotein of the TNF receptor superfamily. CD30 was originally identified as a cell surface antigen of Hodgkins and Reed-Sternberg cells using monoclonal antibody Ki-1. The ligand for CD30 is CD30L (CD153). The binding of CD30 to CD30L mediates pleiotropic effects including cell proliferation, activation, differentiation, and apoptotic cell death. CD30 has a critical role in the pathophysiology of Hodgkin's disease and other CD30+ lymphomas. CD30 acts as a costimulatory molecule in thymic negative selection. In addition to its expression on Hodgkin's and Reed-Sternberg cells, CD30 is also found in some non-Hodgkin's lymphomas (including Burkitt's lymphomas), virus-infected T and B cells, and on normal T and B cells after activation. In T cells, CD30 expression is present on a subset of T cells that produce Th2-type cytokines and on CD4+/CD8+ thymocytes that co-express CD45RO and the IL4 receptor. Soluble form of CD30 (sCD30) serves as a marker reflecting Th2 immune response.Synonyms: CD30L receptor, D1S166E, KI-1 antigen, Lymphocyte activation antigen CD30, TNFRSF8, Tumor necrosis factor receptor superfamily member 8
Gene ID 943
Research Area Cancer, Innate Immunity, Cytokines, CD Antigens, Surface Receptors of Immune Cells
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Concentration 1.0 mg/mL
Buffer Phosphate buffered saline (PBS), pH 7.4 containing 15 mM Sodium Azide as preservative
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Background publications Pavlov, Martins, Delgado: "Development and validation of a fluorescent microsphere immunoassay for soluble CD30 testing." in: Clinical and vaccine immunology : CVI, Vol. 16, Issue 9, pp. 1327-31, 2009 (PubMed).

Bekiaris, Withers, Glanville et al.: "Role of CD30 in B/T segregation in the spleen." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 179, Issue 11, pp. 7535-43, 2007 (PubMed).

Wright, Rumble, Duckett: "CD30 activates both the canonical and alternative NF-kappaB pathways in anaplastic large cell lymphoma cells." in: The Journal of biological chemistry, Vol. 282, Issue 14, pp. 10252-62, 2007 (PubMed).

Zeiser, Nguyen, Hou et al.: "Early CD30 signaling is critical for adoptively transferred CD4+CD25+ regulatory T cells in prevention of acute graft-versus-host disease." in: Blood, Vol. 109, Issue 5, pp. 2225-33, 2007 (PubMed).

Polte, Behrendt, Hansen: "Direct evidence for a critical role of CD30 in the development of allergic asthma." in: The Journal of allergy and clinical immunology, Vol. 118, Issue 4, pp. 942-8, 2006 (PubMed).

Fischer, Harvima, Carvalho et al.: "Mast cell CD30 ligand is upregulated in cutaneous inflammation and mediates degranulation-independent chemokine secretion." in: The Journal of clinical investigation, Vol. 116, Issue 10, pp. 2748-56, 2006 (PubMed).

Kennedy, Willis, Armitage: "Deciphering CD30 ligand biology and its role in humoral immunity." in: Immunology, Vol. 118, Issue 2, pp. 143-52, 2006 (PubMed).

Blazar, Levy, Mak et al.: "CD30/CD30 ligand (CD153) interaction regulates CD4+ T cell-mediated graft-versus-host disease." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 173, Issue 5, pp. 2933-41, 2004 (PubMed).

Lamarque, Rodière, Pasqual et al.: "[Mammotomography, a new technic of breast examination]." in: La Nouvelle presse médicale, Vol. 5, Issue 43, pp. 2933-8, 1977 (PubMed).

Validation Images
Catalog No. ABIN614243
286.00 $
Plus shipping costs $45.00
Quantity
Price
0.1 mg
286.00 $

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