CD81 antibody (PE)

Catalog No. ABIN614803

Product Details anti-CD81 Antibody (PE)

Target: CD81

Reactivity: Human, Rabbit, Cat

Host: Mouse

Clonality: Monoclonal

Conjugate: This CD81 antibody is conjugated to PE

Application: Flow Cytometry (FACS)

Specificity: This antibody CD81, a 25 kDa member of the tetraspanin family, expressed on majority of cells.

Cross-Reactivity (Details): Species reactivity (tested):Human, Feline (Cat), Rabbit

Immunogen: MOLT-4 (human T-ALL cell line)

Clone: M38

Isotype: IgG1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Buffer: Phosphate buffered saline (PBS) containing 15 mM sodium azide and 0.2 % (w/v) high-grade protease free Bovine Serum Albumin (BSA) as a stabilizing agent

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: DO NOT FREEZE! This product is photosensitive and should be protected from light.

Storage: 4 °C

References for anti-CD81 antibody (PE) (ABIN614803)

Porchet, Probst, Dráberová, Dráber, Riederer, Riederer: "Differential subcellular localization of phosphorylated neurofilament and tau proteins in degenerating neurons of the human entorhinal cortex." in: Neuroreport, Vol. 14, Issue 7, pp. 929-33, (2003) (PubMed).

Escola, Kleijmeer, Stoorvogel, Griffith, Yoshie, Geuze: "Selective enrichment of tetraspan proteins on the internal vesicles of multivesicular endosomes and on exosomes secreted by human B-lymphocytes." in: The Journal of biological chemistry, Vol. 273, Issue 32, pp. 20121-7, (1998) (PubMed).

Imai, Kakizaki, Nishimura, Yoshie: "Molecular analyses of the association of CD4 with two members of the transmembrane 4 superfamily, CD81 and CD82." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 155, Issue 3, pp. 1229-39, (1995) (PubMed).

Imai, Yoshie et al.: "C33 antigen and M38 antigen recognized by monoclonal antibodies inhibitory to syncytium formation by human T cell leukemia virus type 1 are both members of the transmembrane 4 superfamily and ..." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 151, Issue 11, pp. 6470-81, (1994) (PubMed).

Kiyotaki, Cooper, Bertoli, Kearney, Kubagawa: "Monoclonal anti-Id antibodies react with varying proportions of human B lineage cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 138, Issue 12, pp. 4150-8, (1987) (PubMed).

Target Details for CD81

Target: CD81

Alternative Name: CD81 / TAPA1 (CD81 Products)

Background: CD81 (TAPA-1), a member of the tetraspanin family, is expressed on virtually all nucleated cells, but above all on germinal center B cells. CD81 forms complexes with other tetraspanin proteins, integrins, coreceptors, MHC class I and II molecules, and influences adhesion, morphology, activation, proliferation and differentiation of B, T and other cells - e.g. in muscles CD81 promotes cell fusion and myotube maintenance. CD81 has been also identified as a receptor for the hepatitis C virus.Synonyms: 26 kDa cell surface protein TAPA-1, Target of the antiproliferative antibody 1

Gene ID: 975

NCBI Accession: NP_004347

UniProt: P60033

Pathways: Inositol Metabolic Process, Hepatitis C