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Details for Product No. ABIN654230

Leucyl/cystinyl Aminopeptidase (LNPEP) (N-Term), (AA 23-52) antibody

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Synonyms IRAP, P-LAP, Vp165, CAP, PLAP, 2010309L07Rik, 4732490P18Rik, gp160, vp165, fb73h12, wu:fb73h12, zgc:66103
»Alternatives N-Term, AA 23-52
»Alternatives Human
»Alternatives Rabbit
Clonality (Clone) Polyclonal ()
»Alternatives Western Blotting (WB), Immunohistochemistry (IHC), Flow Cytometry (FACS)
Pubmed 2 references available
Catalog no. ABIN654230
Quantity 400 µL
291.50 $   Plus shipping costs $45.00
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Immunogen This LNPEP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 23-52 AA from the N-terminal region of human LNPEP.
Clone RB27638
Isotype Ig
Specificity This LNPEP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 16-46 amino acids from the N-terminal region of human LNPEP.
Predicted Reactivity Mouse (Murine),Rat (Rattus)
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name LNPEP
Background This gene encodes a zinc-dependent aminopeptidase that cleaves vasopressin, oxytocin, lys-bradykinin, met-enkephalin, dynorphin A and other peptide hormones. The protein can be secreted in maternal serum, reside in intracellular vesicles with the insulin-responsive glucose transporter GLUT4, or form a type II integral membrane glycoprotein. The protein catalyzes the final step in the conversion of angiotensinogen to angiotensin IV (AT4) and is also a receptor for AT4. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq].
Synonyms: Leucyl-cystinyl aminopeptidase,LNPEP,OTASE
Molecular Weight 117349 DA
Gene ID 4012
UniProt NP_005566.2, NP_787116.2, Q9UIQ6
Research Area Phospho-specific antibodies, Cell Signaling, Cell Structure, Protein Modifications, Metabolism
Application Notes Recommend dilutions: WB : 1:1000,IHC : 1:50-100,FC : 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Background publications Saveanu, Carroll, Weimershaus et al.: "IRAP identifies an endosomal compartment required for MHC class I cross-presentation." in: Science (New York, N.Y.), Vol. 325, Issue 5937, pp. 213-7, 2009 (PubMed).

Georgiadou, Hearn, Evnouchidou et al.: "Placental leucine aminopeptidase efficiently generates mature antigenic peptides in vitro but in patterns distinct from endoplasmic reticulum aminopeptidase 1." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 185, Issue 3, pp. 1584-92, 2010 (PubMed).

Alternatives for antigen "Leucyl/cystinyl Aminopeptidase (LNPEP)", type "Antibodies"
Hosts (15), (2), (1)
Reactivities (16), (4), (2)
Applications (16), (11), (6), (4), (3), (2), (2), (2), (1)
Epitopes (6), (3), (2), (2), (1), (1)