Itchy E3 Ubiquitin Protein Ligase Homolog (Mouse) (ITCH) (AA 509-536), (Center) antibody

Details for Product No. ABIN657549
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Antigen
Epitope
AA 509-536, Center
(14), (10), (8), (7), (3), (2), (2), (1), (1), (1), (1), (1), (1)
Reactivity
Mouse (Murine)
(43), (21), (1)
Host
Rabbit
(37), (8), (6)
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
(3), (3), (1), (1), (1), (1)
Application
Western Blotting (WB)
(35), (31), (9), (4), (3), (2), (2), (1)
Pubmed 1 reference available
Quantity 400 μL
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Catalog No. ABIN657549
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Immunogen This ITCH antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 509-536 AA from the Central region of human ITCH.
Clone RB33154
Isotype Ig
Specificity This ITCH antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 508-536 amino acids from the Central region of human ITCH.
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name ITCH
Background Atrophin-1 contains a polyglutamine repeat, expansion of which is responsible for dentatorubral and pallidoluysian atrophy. The protein encoded by this gene interacts with atrophin-1. This encoded protein is a closely related member of the NEDD4-like protein family. This family of proteins are E3 ubiquitin-ligase molecules and regulate key trafficking decisions, including targeting of proteins to proteosomes or lysosomes. This encoded protein contains four tandem WW domains and a HECT (homologous to the E6-associated protein carboxyl terminus) domain. It can act as a transcriptional corepressor of p45/NFE2 and may participate in the regulation of immune responses by modifying Notch-mediated signaling. It is highly similar to the mouse Itch protein, which has been implicated in the regulation and differentiation of erythroid and lymphoid cells.
Synonyms: E3 ubiquitin-protein ligase Itchy homolog,ITCH,
Molecular Weight 102803 DA
Gene ID 83737
NCBI Accession NP_113671
UniProt Q96J02
Research Area Ubiquitin-related antibodies, Apoptosis/Necrosis, Phospho-specific antibodies, Cell Signaling, Cell Structure, Protein Modifications
Application Notes WB = 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment ITCH Antibody (Center) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the at -20 °C.
Expiry Date 6 months
Supplier Images
anti-Itchy E3 Ubiquitin Protein Ligase Homolog (Mouse) (ITCH) (AA 509-536), (Center) antibody ITCH Antibody (Center) (ABIN657549) western blot analysis in mouse brain tissue lysates (35 µg/lane). This demonstrates the ITCH antibody detected the ITCH protein (arrow).
Background publications Lohr, Molleston, Strauss et al.: "Human ITCH E3 ubiquitin ligase deficiency causes syndromic multisystem autoimmune disease." in: American journal of human genetics, Vol. 86, Issue 3, pp. 447-53, 2010 (PubMed).

Validation Images
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