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Details for Product No. ABIN657549

Itchy E3 Ubiquitin Protein Ligase Homolog (Mouse) (ITCH) (AA 509-536), (Center) antibody

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Antigen
Synonyms AIF4, AIP4, NAPP1, dJ468O1.1
Epitope
»Alternatives AA 509-536, Center
Reactivity
»Alternatives Mouse (Murine)
Host
»Alternatives Rabbit
Clonality (Clone) Polyclonal ()
Application
»Alternatives Western Blotting (WB)
Pubmed 1 reference available
Catalog no. ABIN657549
Quantity 400 µL
Price
291.50 $   Plus shipping costs $45.00
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Availability Will be delivered in 2 to 3 Business Days
Immunogen This ITCH antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 509-536 AA from the Central region of human ITCH.
Clone RB33154
Isotype Ig
Specificity This ITCH antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 508-536 amino acids from the Central region of human ITCH.
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name ITCH
Background Atrophin-1 contains a polyglutamine repeat, expansion of which is responsible for dentatorubral and pallidoluysian atrophy. The protein encoded by this gene interacts with atrophin-1. This encoded protein is a closely related member of the NEDD4-like protein family. This family of proteins are E3 ubiquitin-ligase molecules and regulate key trafficking decisions, including targeting of proteins to proteosomes or lysosomes. This encoded protein contains four tandem WW domains and a HECT (homologous to the E6-associated protein carboxyl terminus) domain. It can act as a transcriptional corepressor of p45/NFE2 and may participate in the regulation of immune responses by modifying Notch-mediated signaling. It is highly similar to the mouse Itch protein, which has been implicated in the regulation and differentiation of erythroid and lymphoid cells.
Synonyms: E3 ubiquitin-protein ligase Itchy homolog,ITCH,
Molecular Weight 102803 DA
Gene ID 83737
UniProt Q96J02, NP_113671.3
Research Area Ubiquitin-related antibodies, Apoptosis/Necrosis, Phospho-specific antibodies, Cell Signaling, Cell Structure, Protein Modifications
Application Notes Recommend dilutions: WB : 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment ITCH Antibody (Center) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the at -20 °C.
Expiry Date 6 months
Background publications Lohr, Molleston, Strauss et al.: "Human ITCH E3 ubiquitin ligase deficiency causes syndromic multisystem autoimmune disease." in: American journal of human genetics, Vol. 86, Issue 3, pp. 447-53, 2010 (PubMed).

Alternatives for antigen "Itchy E3 Ubiquitin Protein Ligase Homolog (Mouse) (ITCH)", type "Antibodies"
Hosts (19), (6), (2)
Reactivities (23), (12), (1), (1)
Applications (20), (19), (5), (1), (1), (1)
Epitopes (5), (5), (3), (1), (1), (1), (1), (1)
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