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Splicing Factor 3b, Subunit 1, 155kDa (SF3B1) (N-Term), (AA 374-402) antibody

Details for Product No. ABIN657676
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Antigen
Synonyms SF3B1, wu:fb99f09, 155kDa, 2810001M05Rik, AA409119, Prp10, SAP155, SF3b155, TA-8, Targ4, Sap155, hsh155, prp10, prpf10, sap155, Hsh155, MDS, PRP10, PRPF10
Epitope
N-Term, AA 374-402
(11), (7), (3), (2), (1), (1), (1), (1), (1)
Reactivity
Human
(35), (23), (16), (4), (4), (4), (3), (3), (1)
Host
Rabbit
(36), (4)
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
(2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB), Immunohistochemistry (IHC)
(30), (11), (10), (10), (6), (4), (3), (2)
Pubmed 3 references available
Quantity 400 µL
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Catalog No. ABIN657676
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Immunogen This SF3B1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 374-402 AA from the N-terminal region of human SF3B1.
Clone RB33758
Isotype Ig
Specificity This SF3B1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 373-402 amino acids from the N-terminal region of human SF3B1.
Predicted Reactivity Mouse (Murine),Xenopus laevis
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name SF3B1
Background This gene encodes subunit 1 of the splicing factor 3b protein complex. Splicing factor 3b, together with splicing factor 3a and a 12S RNA unit, forms the U2 small nuclear ribonucleoproteins complex (U2 snRNP). The splicing factor 3b/3a complex binds pre-mRNA upstream of the intron's branch site in a sequence independent manner and may anchor the U2 snRNP to the pre-mRNA. Splicing factor 3b is also a component of the minor U12-type spliceosome. The carboxy-terminal two-thirds of subunit 1 have 22 non-identical, tandem HEAT repeats that form rod-like, helical structures. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq].
Synonyms: Splicing factor 3B subunit 1,SF3B1,SAP155
Molecular Weight 145830 DA
Gene ID 23451
UniProt NP_036565.2, O75533
Research Area Signaling, Phospho-specific antibodies, Protein Modifications, Transcription Factors, Cell Structure
Application Notes WB = 1:1000, IHC = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 0.37 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment SF3B1 Antibody (N-term) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the at -20 °C.
Expiry Date 6 months
Supplier Images
anti-Splicing Factor 3b, Subunit 1, 155kDa (SF3B1) (N-Term), (AA 374-402) antibody SF3B1 Antibody (N-term) (ABIN657676) western blot analysis in CEM cell line lysates (35 µg/lane). This demonstrates the SF3B1 antibody detected the SF3B1 protein (arrow).
Background publications Pessa, Will, Meng et al.: "Minor spliceosome components are predominantly localized in the nucleus." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 105, Issue 25, pp. 8655-60, 2008 (PubMed).

Tanuma, Kim, Beullens et al.: "Nuclear inhibitor of protein phosphatase-1 (NIPP1) directs protein phosphatase-1 (PP1) to dephosphorylate the U2 small nuclear ribonucleoprotein particle (snRNP) component, spliceosome-associated protein 155 (Sap155)." in: The Journal of biological chemistry, Vol. 283, Issue 51, pp. 35805-14, 2008 (PubMed).

Corsini, Hothorn, Stier et al.: "Dimerization and protein binding specificity of the U2AF homology motif of the splicing factor Puf60." in: The Journal of biological chemistry, Vol. 284, Issue 1, pp. 630-9, 2008 (PubMed).

Validation Images
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