Dual-Specificity tyrosine-(Y)-phosphorylation Regulated Kinase 2 (DYRK2) (AA 521-549), (C-Term) antibody

Details for Product No. ABIN657991
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Antigen
Epitope
AA 521-549, C-Term
(26), (18), (15), (5), (4), (2), (2), (1), (1), (1), (1)
Reactivity
Human, Mouse (Murine)
(69), (21), (12)
Host
Rabbit
(64), (12), (1)
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
(5), (5), (5), (4), (4), (4), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(65), (35), (34), (12), (10), (6), (3), (2), (1)
Pubmed 1 reference available
Quantity 400 μL
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Immunogen This Mouse Dyrk2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 521-549 AA from the C-terminal region of mouse Dyrk2.
Clone RB34467
Isotype Ig
Specificity This Mouse Dyrk2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 520-549 amino acids from the C-terminal region of human Mouse Dyrk2.
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name Dyrk2 (DYRK2 Antibody Abstract)
Background Role in the regulation of cellular growth and/or development. Regulates TP53 by phosphorylation on Ser-46 to induce apoptosis in response to DNA damage, functioning downstream of ATM. Inactivates GYS1 by phosphorylation at Ser-641, and potentially also a second phosphorylation site, thus regulating glycogen synthesis. Phosphorylates EIF2B5 at Ser-544, enabling its subsequent phosphorylation and inhibition by GSK3, and may play a more general role in the priming of GSK3 substrates (By similarity).
Synonyms: Dual specificity tyrosine-phosphorylation-regulated kinase 2,69181,
Molecular Weight 66556 DA
Gene ID 69181
NCBI Accession NP_001014412
UniProt Q5U4C9
Research Area Ubiquitin-related antibodies, Apoptosis/Necrosis, Phospho-specific antibodies, Cell Signaling, Protein Modifications, Chromatin, Signaling, Cell Structure
Application Notes WB = 1:1000, IHC (p) = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Mouse Dyrk2 Antibody (C-term) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the at -20 °C.
Expiry Date 6 months
Supplier Images
anti-Dual-Specificity tyrosine-(Y)-phosphorylation Regulated Kinase 2 (DYRK2) (AA 521-549), (C-Term) antibody Mouse Dyrk2 Antibody (C-term) (ABIN657991) western blot analysis in K562 cell line ly...
Background publications Guo, Williams, Schug et al.: "DYRK1A and DYRK3 promote cell survival through phosphorylation and activation of SIRT1." in: The Journal of biological chemistry, Vol. 285, Issue 17, pp. 13223-32, 2010 (PubMed).

Validation Images
Catalog No. ABIN657991
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