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Dual-Specificity tyrosine-(Y)-phosphorylation Regulated Kinase 2 (DYRK2) (AA 521-549), (C-Term) antibody

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Synonyms DYRK2, fc18c09, si:ch211-266a5.8, wu:fa09g03, wu:fc18c09, 1810038L18Rik
AA 521-549, C-Term
(28), (20), (15), (6), (5), (4), (2), (1), (1), (1), (1), (1)
Human, Mouse (Murine)
(81), (22), (13)
(72), (16), (1)
Clonality (Clone)
Polyclonal ()
(5), (5), (5), (4), (4), (4), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(72), (45), (37), (13), (11), (6), (3), (2), (1)
Pubmed 1 reference available
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Quantity 400 μL
Shipping to United States ( )
Availability Will be delivered in 2 to 4 Business Days
Immunogen This Mouse Dyrk2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 521-549 AA from the C-terminal region of mouse Dyrk2.
Clone RB34467
Isotype Ig
Specificity This Mouse Dyrk2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 520-549 amino acids from the C-terminal region of human Mouse Dyrk2.
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name Dyrk2 (DYRK2 Antibody Abstract)
Background Role in the regulation of cellular growth and/or development. Regulates TP53 by phosphorylation on Ser-46 to induce apoptosis in response to DNA damage, functioning downstream of ATM. Inactivates GYS1 by phosphorylation at Ser-641, and potentially also a second phosphorylation site, thus regulating glycogen synthesis. Phosphorylates EIF2B5 at Ser-544, enabling its subsequent phosphorylation and inhibition by GSK3, and may play a more general role in the priming of GSK3 substrates (By similarity).
Synonyms: Dual specificity tyrosine-phosphorylation-regulated kinase 2,69181,
Molecular Weight 66556 DA
Gene ID 69181
NCBI Accession NP_001014412
UniProt Q5U4C9
Research Area Ubiquitin-related antibodies, Apoptosis/Necrosis, Phospho-specific antibodies, Cell Signaling, Protein Modifications, Chromatin, Signaling, Cell Structure
Application Notes WB = 1:1000, IHC (p) = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Mouse Dyrk2 Antibody (C-term) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the at -20 °C.
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-Dual-Specificity tyrosine-(Y)-phosphorylation Regulated Kinase 2 (DYRK2) (AA 521-549), (C-Term) antibody (ABIN657991) Mouse Dyrk2 Antibody (C-term) (ABIN657991) western blot analysis in K562 cell line ly...
Background publications Guo, Williams, Schug et al.: "DYRK1A and DYRK3 promote cell survival through phosphorylation and activation of SIRT1." in: The Journal of biological chemistry, Vol. 285, Issue 17, pp. 13223-32, 2010 (PubMed).

Catalog No. ABIN657991
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