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DYRK2 antibody (AA 502-601)

DYRK2 Reactivity: Human ELISA, IHC Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN7150791
  • Target See all DYRK2 Antibodies
    DYRK2 (Dual-Specificity tyrosine-(Y)-phosphorylation Regulated Kinase 2 (DYRK2))
    Binding Specificity
    • 15
    • 11
    • 8
    • 8
    • 5
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 502-601
    Reactivity
    • 42
    • 32
    • 22
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Human
    Host
    • 55
    • 7
    • 1
    Rabbit
    Clonality
    • 56
    • 7
    Polyclonal
    Conjugate
    • 26
    • 5
    • 5
    • 4
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This DYRK2 antibody is un-conjugated
    Application
    • 57
    • 32
    • 26
    • 13
    • 13
    • 9
    • 5
    • 3
    • 3
    • 2
    • 2
    • 1
    ELISA, Immunohistochemistry (IHC)
    Cross-Reactivity
    Human
    Purification
    Antigen Affinity Purified
    Immunogen
    Recombinant Human Dual specificity tyrosine-phosphorylation-regulated kinase 2 protein (502-601AA)
    Isotype
    IgG
    Top Product
    Discover our top product DYRK2 Primary Antibody
  • Application Notes
    Recommended dilution: IHC:1:20-1:200,
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C,-80 °C
    Storage Comment
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • Target
    DYRK2 (Dual-Specificity tyrosine-(Y)-phosphorylation Regulated Kinase 2 (DYRK2))
    Alternative Name
    DYRK2 (DYRK2 Products)
    Synonyms
    DYRK2 antibody, fc18c09 antibody, si:ch211-266a5.8 antibody, wu:fa09g03 antibody, wu:fc18c09 antibody, 1810038L18Rik antibody, dual specificity tyrosine phosphorylation regulated kinase 2 antibody, dual specificity tyrosine-phosphorylation-regulated kinase 2 antibody, dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2 antibody, DYRK2 antibody, CpipJ_CPIJ014802 antibody, dyrk2 antibody, Dyrk2 antibody
    Background

    Background: Serine/threonine-protein kinase involved in the regulation of the mitotic cell cycle, cell proliferation, apoptosis, organization of the cytoskeleton and neurite outgrowth. Functions in part via its role in ubiquitin-dependent proteasomal protein degradation. Functions downstream of ATM and phosphorylates p53/TP53 at \\\'Ser-46\\\', and thereby contributes to the induction of apoptosis in response to DNA damage. Phosphorylates NFATC1, and thereby inhibits its accumulation in the nucleus and its transcription factor activity. Phosphorylates EIF2B5 at \\\'Ser-544\\\', enabling its subsequent phosphorylation and inhibition by GSK3B. Likewise, phosphorylation of NFATC1, CRMP2/DPYSL2 and CRMP4/DPYSL3 promotes their subsequent phosphorylation by GSK3B. May play a general role in the priming of GSK3 substrates. Inactivates GYS1 by phosphorylation at \\\'Ser-641\\\', and potentially also a second phosphorylation site, thus regulating glycogen synthesis. Mediates EDVP E3 ligase complex formation and is required for the phosphorylation and subsequent degradation of KATNA1. Phosphorylates TERT at \\\'Ser-457\\\', promoting TERT ubiquitination by the EDVP complex. Phosphorylates SIAH2, and thereby increases its ubiquitin ligase activity. Promotes the proteasomal degradation of MYC and JUN, and thereby regulates progress through the mitotic cell cycle and cell proliferation. Promotes proteasomal degradation of GLI2 and GLI3, and thereby plays a role in smoothened and sonic hedgehog signaling. Plays a role in cytoskeleton organization and neurite outgrowth via its phosphorylation of DCX and DPYSL2. Phosphorylates CRMP2/DPYSL2, CRMP4/DPYSL3, DCX, EIF2B5, EIF4EBP1, GLI2, GLI3, GYS1, JUN, MDM2, MYC, NFATC1, p53/TP53, TAU/MAPT and KATNA1. Can phosphorylate histone H1, histone H3 and histone H2B (in vitro). Can phosphorylate CARHSP1 (in vitro).

    Aliases: 1810038L18Rik antibody, Dual specificity tyrosine (Y) phosphorylation regulated kinase 2 antibody, Dual specificity tyrosine phosphorylation regulated kinase 2 antibody, Dual specificity tyrosine-phosphorylation-regulated kinase 2 antibody, DYRK2 antibody, DYRK2_HUMAN antibody, EC 2.7.12.1 antibody, FLJ21217 antibody, FLJ21365 antibody

    UniProt
    Q92630
    Pathways
    Regulation of Carbohydrate Metabolic Process
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