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Details for Product No. ABIN657991

Dual-Specificity tyrosine-(Y)-phosphorylation Regulated Kinase 2 (DYRK2) (C-Term), (AA 521-549) antibody

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Antigen
Synonyms 1810038L18Rik, fc18c09, wu:fa09g03, wu:fc18c09, si:ch211-266a5.8, DYRK2
Epitope
»Alternatives C-Term, AA 521-549
Reactivity
»Alternatives Human, Mouse (Murine)
Host
»Alternatives Rabbit
Clonality (Clone) Polyclonal ()
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Western Blotting (WB), Immunohistochemistry (IHC)
Pubmed 1 reference available
Catalog no. ABIN657991
Quantity 400 µL
Price
291.50 $   Plus shipping costs $45.00
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Availability Will be delivered in 2 to 3 Business Days
Immunogen This Mouse Dyrk2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 521-549 AA from the C-terminal region of mouse Dyrk2.
Clone RB34467
Isotype Ig
Specificity This Mouse Dyrk2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 520-549 amino acids from the C-terminal region of human Mouse Dyrk2.
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name Dyrk2
Background Role in the regulation of cellular growth and/or development. Regulates TP53 by phosphorylation on Ser-46 to induce apoptosis in response to DNA damage, functioning downstream of ATM. Inactivates GYS1 by phosphorylation at Ser-641, and potentially also a second phosphorylation site, thus regulating glycogen synthesis. Phosphorylates EIF2B5 at Ser-544, enabling its subsequent phosphorylation and inhibition by GSK3, and may play a more general role in the priming of GSK3 substrates (By similarity).
Synonyms: Dual specificity tyrosine-phosphorylation-regulated kinase 2,69181,
Molecular Weight 66556 DA
Gene ID 69181
UniProt NP_001014412.1, Q5U4C9
Research Area Ubiquitin-related antibodies, Apoptosis/Necrosis, Phospho-specific antibodies, Cell Signaling, Protein Modifications, Chromatin, Signaling, Cell Structure
Application Notes Recommend dilutions: WB : 1:1000,IHC : 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Mouse Dyrk2 Antibody (C-term) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the at -20 °C.
Expiry Date 6 months
Background publications Guo, Williams, Schug et al.: "DYRK1A and DYRK3 promote cell survival through phosphorylation and activation of SIRT1." in: The Journal of biological chemistry, Vol. 285, Issue 17, pp. 13223-32, 2010 (PubMed).

Alternatives for antigen "Dual-Specificity tyrosine-(Y)-phosphorylation Regulated Kinase 2 (DYRK2)", type "Antibodies"
Hosts (37), (11)
Reactivities (47), (14), (12), (12), (12), (12), (4), (3)
Applications (36), (19), (11), (10), (5), (1)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (13), (5), (4), (4), (1), (1), (1), (1)
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