Cyclin-Dependent Kinase 5 (CDK5) antibody

Details for Product No. ABIN782438
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Antigen
Synonyms PSSALRE, AW048668, Crk6, CDK5, CG8203, DmCdk5, Dmel\\CG8203, cdk5, zgc:101604
Reactivity
Human, Mouse (Murine), Rat (Rattus)
(169), (91), (80), (30), (19), (18), (12), (9), (5), (4), (3), (3), (2), (1), (1)
Host
Mouse
(130), (55)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1)
Application
Immunohistochemistry (Frozen Sections) (IHC (fro)), Western Blotting (WB)
(158), (78), (40), (40), (30), (23), (19), (17), (8), (5), (4), (4), (3), (1)
Pubmed 4 references available
Quantity 0.1 mL
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Catalog No. ABIN782438
390.50 $
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Immunogen Purified Rat Cdk5.
Clone 1H3
Isotype IgG
Specificity Specific for the ~ 28 kDa Cdk5 protein in Western blots of Rat striatal lysate. The antibody shows no cross reactivity with the CDK5 cofactor p35 or its degradation product p25.
Cross-Reactivity (Details) Species reactivity (tested):Human, Mouse, Rat.
Purification Protein G Chromatography.
Alternative Name CDK5
Background The neuronal protein kinase, Cdk5 has been implicated in a vast array of normal neuronal functions including regulation of neurotransmitter synthesis (Kansy J et al., 2004), the presynaptic vesicle cycle (Nguyen, C. & Bibb, JA 2003), neurotransmitter receptor trafficking and dopamine neurotransmission (Bibb, JA et al. 1999). At the same time Cdk5 has been implicated in a plethora of neurological and neuropsychiatric disorders including Alzheimer's, Parkinson's, Huntington's, epilepsy, schizophrenia, and drug addiction. Detection of Cdk5 in normal samples as well as tissue undergoing neurodegeneration may advance studies in these areas. Moreover, this antibody may allow more accurate postmortem evaluations of Cdk5 protein expression, and thus serve as a valuable new reagent for neuropathology.Synonyms: Cell division protein kinase 5, Cyclin-dependent kinase 5, PSSALRE, Serine/threonine-protein kinase PSSALRE, TPKII catalytic subunit, Tau protein kinase II catalytic subunit
Gene ID 140908
NCBI Accession NP_543161
UniProt Q03114
Research Area Cell Cycle, Kinases/Phosphatases
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Buffer 10 mM HEPES ( pH 7.5), 150 mM NaCl, 100 μg/mL BSA and 50 % Glycerol.
Handling Advice Avoid repeated freezing and thawing.
Storage -20 °C
Storage Comment Store the antibody undiluted (in aliquots) at -20 °C.
Supplier Images
anti-Cyclin-Dependent Kinase 5 (CDK5) antibody anti-Cyclin-Dependent Kinase 5 (CDK5) antibody
Background publications Bibb, Snyder, Nishi et al.: "Phosphorylation of DARPP-32 by Cdk5 modulates dopamine signalling in neurons." in: Nature, Vol. 402, Issue 6762, pp. 669-71, 2000 (PubMed).

Nguyen, Bibb: "Cdk5 and the mystery of synaptic vesicle endocytosis." in: The Journal of cell biology, Vol. 163, Issue 4, pp. 697-9, 2003 (PubMed).

Kansy, Daubner, Nishi et al.: "Identification of tyrosine hydroxylase as a physiological substrate for Cdk5." in: Journal of neurochemistry, Vol. 91, Issue 2, pp. 374-84, 2004 (PubMed).

Lagace, Benavides, Kansy et al.: "Cdk5 is essential for adult hippocampal neurogenesis." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 105, Issue 47, pp. 18567-71, 2008 (PubMed).

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