ZBP1 antibody (C-Term)

Catalog No. ABIN783819

This anti-ZBP1 antibody is a Rabbit Polyclonal antibody detecting ZBP1 in WB, IHC (p) and EIA. Suitable for Human, Mouse and Rat.

Quick Overview for ZBP1 antibody (C-Term) (ABIN783819)

Target: ZBP1 (Z-DNA Binding Protein 1 (ZBP1))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ZBP1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Product Details anti-ZBP1 Antibody

Binding Specificity: C-Term

Specificity: This antibody reacts to ZBP1.

Purification: Affinity chromatography

Immunogen: 18 amino acid peptide from near the carboxy terminus of human ZBP1.

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 1,0 mg/mL

Buffer: PBS containing 0.02 % sodium azide as preservative

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Store the antibody undiluted at 2-8 °C.

Target Details for ZBP1

Target: ZBP1 (Z-DNA Binding Protein 1 (ZBP1))

Alternative Name: ZBP1

Background: Z-DNA binding protein 1 (ZBP1) belongs to a family of proteins that contain the Za domain which binds specifically to left-handed Z-DNA and Z-RNA. ZBP1 was initially identified as a novel gene that was up-regulated in activated macrophages in mice bearing ascites tumors, suggesting that is may play a role in processes such as host response in neoplasia. More recent reports indicate that the cytosolic ZBP1 has can act like the toll-like receptor TLR9 by detecting cytosolic double-stranded (ds) DNA and trigger induction of type I interferon and other innate immune responses. It is thought that the binding of ZBP1 to dsDNA enhances its association with innate immune response proteins such as the IRF3 transcription factor and the serine/threonine kinase TBK1 (also known as NAK). Multiple isoforms of ZBP1 are known to exist.Synonyms: C20orf183, DLM1, Z-DNA-binding protein 1

Gene ID: 81030

NCBI Accession: NP_001153889

UniProt: Q9H171