Absent in Melanoma 2 (AIM2) (N-Term), (AA 11-40) antibody

Details for Product No. ABIN950314
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Synonyms AIM2, PYHIN4, Gm1313, Ifi210
N-Term, AA 11-40
(18), (14), (13), (12), (9), (8), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
(108), (15), (14), (1), (1)
(66), (31), (12)
(6), (6), (6), (5), (5), (5), (1), (1), (1), (1), (1), (1), (1), (1)
Enzyme Immunoassay (EIA), Flow Cytometry (FACS), Western Blotting (WB)
(96), (65), (19), (15), (11), (10), (7), (7), (4), (3), (3), (1), (1), (1)
Pubmed 6 references available
Quantity 0.4 mL
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Catalog No. ABIN950314
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Immunogen KLH conjugated synthetic peptide between 11~40 amino acids from the N-terminal region of human AIM2
Isotype Ig
Specificity This antibody reacts to AIM2.
Cross-Reactivity (Details) Species reactivity (tested):Human.
Purification Affinity chromatography on Protein A
Alternative Name AIM2
Background AIM2 is a member of the IFI20X /IFI16 family. It plays a putative role in tumorigenic reversion and may control cell proliferation. Interferon-gamma induces expression of AIM2.Synonyms: Absent in melanoma 2, Interferon-inducible protein AIM2
Gene ID 9447
NCBI Accession NP_004824
Research Area Cancer, Transcription Factors
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS containing 0.09 % (W/V) sodium azide as preservative
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Background publications Patsos, Germann, Gebert et al.: "Restoration of absent in melanoma 2 (AIM2) induces G2/M cell cycle arrest and promotes invasion of colorectal cancer cells." in: International journal of cancer. Journal international du cancer, Vol. 126, Issue 8, pp. 1838-49, 2010 (PubMed).

Hauschild, Schadendorf: "[Working group of the Dermatologic Oncology]." in: Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG, Vol. 7, Issue 8, pp. 726-7, 2009 (PubMed).

Fernandes-Alnemri, Yu, Datta et al.: "AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA." in: Nature, Vol. 458, Issue 7237, pp. 509-13, 2009 (PubMed).

Hornung, Ablasser, Charrel-Dennis et al.: "AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC." in: Nature, Vol. 458, Issue 7237, pp. 514-8, 2009 (PubMed).

Woerner, Kloor, Schwitalle et al.: "The putative tumor suppressor AIM2 is frequently affected by different genetic alterations in microsatellite unstable colon cancers." in: Genes, chromosomes & cancer, Vol. 46, Issue 12, pp. 1080-9, 2007 (PubMed).

Cresswell, Clarke, Jackson et al.: "Biochemical and growth regulatory activities of the HIN-200 family member and putative tumor suppressor protein, AIM2." in: Biochemical and biophysical research communications, Vol. 326, Issue 2, pp. 417-24, 2004 (PubMed).

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