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Absent in Melanoma 2 (AIM2) (N-Term), (AA 11-40) antibody

Details for Product No. ABIN950314
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Antigen
Synonyms PYHIN4, Gm1313, Ifi210, AIM2
Epitope
N-Term, AA 11-40
(9), (8), (7), (4), (3), (2), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(66), (14), (13), (1)
Host
Rabbit
(50), (10), (7)
Clonality
Polyclonal
Conjugate
Un-conjugated
(2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
ELISA, Western Blotting (WB), Flow Cytometry (FACS)
(56), (35), (10), (9), (7), (7), (6), (4), (2), (2)
Pubmed 6 references available
Quantity 0.4 mL
Shipping to United States (Change)
Availability Will be delivered in 6 to 8 Business Days
Catalog No. ABIN950314
357.50 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Immunogen KLH conjugated synthetic peptide between 11~40 amino acids from the N-terminal region of human AIM2
Specificity This antibody reacts to AIM2.
Purification Affinity chromatography on Protein A
Alternative Name AIM2
Background AIM2 is a member of the IFI20X /IFI16 family. It plays a putative role in tumorigenic reversion and may control cell proliferation. Interferon-gamma induces expression of AIM2.
Alternate names: Absent in melanoma 2, Interferon-inducible protein AIM2
Gene ID 9447
NCBI Accession NP_004824
Research Area Cancer, Transcription Factors
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS containing 0.09% (w/v) sodium azide as preservative
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Expiry Date 12 months
Background publications Cresswell, Clarke, Jackson et al.: "Biochemical and growth regulatory activities of the HIN-200 family member and putative tumor suppressor protein, AIM2." in: Biochemical and biophysical research communications, Vol. 326, Issue 2, pp. 417-24, 2004 (PubMed).

Woerner, Kloor, Schwitalle et al.: "The putative tumor suppressor AIM2 is frequently affected by different genetic alterations in microsatellite unstable colon cancers." in: Genes, chromosomes & cancer, Vol. 46, Issue 12, pp. 1080-9, 2007 (PubMed).

Hornung, Ablasser, Charrel-Dennis et al.: "AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC." in: Nature, Vol. 458, Issue 7237, pp. 514-8, 2009 (PubMed).

Fernandes-Alnemri, Yu, Datta et al.: "AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA." in: Nature, Vol. 458, Issue 7237, pp. 509-13, 2009 (PubMed).

Hauschild, Schadendorf: "[Working group of the Dermatologic Oncology]." in: Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG, Vol. 7, Issue 8, pp. 726-7, 2009 (PubMed).

Patsos, Germann, Gebert et al.: "Restoration of absent in melanoma 2 (AIM2) induces G2/M cell cycle arrest and promotes invasion of colorectal cancer cells." in: International journal of cancer. Journal international du cancer, Vol. 126, Issue 8, pp. 1838-49, 2010 (PubMed).

Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN950314
357.50 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
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