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AIM2 antibody (Absent in Melanoma 2) (AA 1-343) Primary Antibody

AIM2 Reactivity: Human IF, WB Host: Mouse Polyclonal unconjugated
Pubmed (4)
Catalog No. ABIN522906
$440.00
Plus shipping costs $45.00
50 μg
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Delivery in 11 to 12 Business Days
  • Target
    AIM2
    Binding Specificity
    AA 1-343
    Reactivity
    Human
    Host
    Mouse
    Clonality
    Polyclonal
    Conjugate
    This AIM2 antibody is un-conjugated
    Application
    Immunofluorescence (IF), Western Blotting (WB)
    Purpose
    Mouse polyclonal antibody raised against a full-length human AIM2 protein.
    Brand
    MaxPab®
    Cross-Reactivity
    Human
    Immunogen

    immunogen: AIM2 (NP_004824, 1 a.a. ~ 343 a.a) full-length human protein.

    Immunogen Sequence: MESKYKEILLLTGLDNITDEELDRFKFFLSDEFNIATGKLHTANRIQVATLMIQNAGAVSAVMKTIRIFQKLNYMLLAKRLQEEKEKVDKQYKSVTKPKPLSQAEMSPAASAAIRNDVAKQRAAPKVSPHVKPEQKQMVAQQESIREGFQKRCLPVMVLKAKKPFTFETQEGKQEMFHATVATEKEFFFVKVFNTLLKDKFIPKRIIIIARYYRHSGFLEVNSASRVLDAESDQKVNVPLNIIRKAGETPKINTLQTQPLGTIVNGLFVVQKVTEKKKNILFDLSDNTGKMEVLGVRNEDTMKCKEGDKVRLTFFTLSKNGEKLQLTSGVHSTIKVIKAKKKT

  • Application Notes
    Optimal working dilution should be determined by the investigator.
    Comment

    Product Quality tested by: Antibody reactive against mammalian transfected lysate.

    Restrictions
    For Research Use only
  • Buffer
    In 1x PBS, pH 7.4
    Handling Advice
    Aliquot to avoid repeated freezing and thawing.
    Storage
    -20 °C
    Storage Comment
    Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
  • Ansari, Singh, Dutta, Veettil, Dutta, Chikoti, Lu, Everly, Chandran: "Constitutive interferon-inducible protein 16-inflammasome activation during Epstein-Barr virus latency I, II, and III in B and epithelial cells." in: Journal of virology, Vol. 87, Issue 15, pp. 8606-23, 2013 (PubMed).

    Lee, Li, Gretz, Gebert, Dihlmann: "Absent in Melanoma 2 (AIM2) is an important mediator of interferon-dependent and -independent HLA-DRA and HLA-DRB gene expression in colorectal cancers." in: Oncogene, Vol. 31, Issue 10, pp. 1242-53, 2012 (PubMed).

    Wang, Hsu, Chen, Liang, Chen, Ojcius, Tsang, Hsueh, Wu, Chang: "Interactome-wide analysis identifies end-binding protein 1 as a crucial component for the speck-like particle formation of activated absence in melanoma 2 (AIM2) inflammasomes." in: Molecular & cellular proteomics : MCP, Vol. 11, Issue 11, pp. 1230-44, 2012 (PubMed).

    Fernandes-Alnemri, Yu, Datta, Wu, Alnemri: "AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA." in: Nature, Vol. 458, Issue 7237, pp. 509-13, 2009 (PubMed).

  • Target
    AIM2
    Alternative Name
    AIM2 (AIM2 Antibody Abstract)
    Synonyms
    AIM2, PYHIN4, Gm1313, Ifi210, absent in melanoma 2, AIM2, Aim2
    Background
    Full Gene Name: absent in melanoma 2
    Synonyms: PYHIN4
    Gene ID
    9447
    NCBI Accession
    NP_004824, NM_004833
    Pathways
    Activation of Innate immune Response, Positive Regulation of Endopeptidase Activity, Inflammasome
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