ARNT2 antibody (Middle Region)

Catalog No. ABIN950512

This Rabbit Polyclonal antibody specifically detects ARNT2 in WB and EIA. It exhibits reactivity toward Human.

Quick Overview for ARNT2 antibody (Middle Region) (ABIN950512)

Target: ARNT2 (Aryl Hydrocarbon Receptor Nuclear Translocator 2 (ARNT2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ARNT2 antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Product Details anti-ARNT2 Antibody

Binding Specificity: AA 248-278, Middle Region

Specificity: This antibody reacts to ARNT2.

Cross-Reactivity (Details): Species reactivity (tested):Human.

Purification: Affinity chromatography on Protein A

Immunogen: KLH conjugated synthetic peptide between 248-278 amino acids from the Central region of human ARNT2

Isotype: Ig Fraction

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.25 mg/mL

Buffer: PBS containing 0.09 % (W/V) sodium azide as preservative

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for ARNT2

Target: ARNT2 (Aryl Hydrocarbon Receptor Nuclear Translocator 2 (ARNT2))

Alternative Name: ARNT2

Background: This gene encodes a member of the basic-helix-loop-helix-Per-Arnt-Sim (bHLH-PAS) superfamily of transcription factors. The encoded protein acts as a partner for several sensor proteins of the bHLH-PAS family, forming heterodimers with the sensor proteins that bind regulatory DNA sequences in genes responsive to developmental and environmental stimuli. Under hypoxic conditions, the encoded protein complexes with hypoxia-inducible factor 1alpha in the nucleus and this complex binds to hypoxia-responsive elements in enhancers and promoters of oxygen-responsive genes. A highly similar protein in mouse forms functional complexes with both aryl hydrocarbon receptors and Single-minded proteins, suggesting addition roles for the encoded protein in the metabolism of xenobiotic compounds and the regulation of neurogenesis, respectively.Synonyms: Aryl hydrocarbon receptor nuclear translocator 2, KIAA0307

Gene ID: 9915

NCBI Accession: NP_055677

Pathways: Warburg Effect