C6orf150 antibody (Middle Region)

Catalog No. ABIN950947

This Rabbit Polyclonal antibody specifically detects C6orf150 in WB and EIA. It exhibits reactivity toward Human.

Quick Overview for C6orf150 antibody (Middle Region) (ABIN950947)

Target: C6orf150 (Chromosome 6 Open Reading Frame 150 (C6orf150))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This C6orf150 antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Product Details anti-C6orf150 Antibody

Binding Specificity: AA 273-303, Middle Region

Specificity: This antibody recognizes Human C6orf150 (CF150). Other species not tested.

Purification: Affinity chromatography on Protein A

Immunogen: KLH conjugated synthetic peptide between 273-303 amino acids from the Central region of human CF150

Isotype: Ig Fraction

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.25 mg/mL

Buffer: PBS, 0.09 % (W/V) Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for C6orf150

Target: C6orf150 (Chromosome 6 Open Reading Frame 150 (C6orf150))

Alternative Name: C6orf150

Background: Function: Nucleotidyltransferase that catalyzes the formation of cyclic GMP-AMP (cGAMP) from ATP and GTP. Catalysis involves both the formation of a 2',5' phosphodiester linkage at the GpA step and the formation of a 3',5' phosphodiester linkage at the ApG step, producing c[G(2',5')pA(3',5')p]. Has antiviral activity by acting as a key cytosolic DNA sensor, the presence of double- stranded DNA (dsDNA) in the cytoplasm being a danger signal that triggers the immune responses. Binds cytosolic DNA directly, leading to activation and synthesis of cGAMP, a second messenger that binds to and activates TMEM173/STING, thereby triggering type-I interferon production. Cellular Location: Cytoplasm, cytosol. Tissue Location: Expressed in the monocytic cell line THP1.Synonyms: Uncharacterized protein C6orf150

Molecular Weight: 58814 Da

Gene ID: 115004

NCBI Accession: NP_612450

Pathways: Activation of Innate immune Response