COPS7A antibody (C-Term)

Catalog No. ABIN951662

Product Details anti-COPS7A Antibody

Target: COPS7A (COP9 Signalosome Complex Subunit 7a (COPS7A))

Binding Specificity: AA 244-274, C-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This COPS7A antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Specificity: This antibody reacts to COPS7A.

Cross-Reactivity (Details): Species reactivity (tested):Human.

Purification: Affinity chromatography on Protein A

Immunogen: KLH conjugated synthetic peptide between 244-274 amino acids from the C-terminal region of human COPS7A

Isotype: Ig Fraction

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.25 mg/mL

Buffer: PBS, 0.09 % (W/V) sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for COPS7A

Target: COPS7A (COP9 Signalosome Complex Subunit 7a (COPS7A))

Alternative Name: COPS7A (COPS7A Products)

Synonyms: D6Ertd35e antibody, CSN7A antibody, COP9 signalosome subunit 7A antibody, COPS7A antibody, Cops7a antibody

Background: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.Synonyms: COP9 signalosome complex subunit 7a, CSN7A, DERP10, Dermal papilla-derived protein 10, JAB1-containing signalosome subunit 7a, SGN7a, Signalosome subunit 7a

Molecular Weight: 30277 Da

Gene ID: 50813

NCBI Accession: NP_001157565

Pathways: Cell Division Cycle