COP9 Constitutive Photomorphogenic Homolog Subunit 7A (Arabidopsis) (COPS7A) (C-Term), (AA 244-274) antibody

Details for Product No. ABIN951662
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Antigen
Synonyms D6Ertd35e, CSN7A
Epitope
C-Term, AA 244-274
(8), (7), (2), (1), (1), (1), (1), (1)
Reactivity
Human
(29), (16), (16), (12), (12)
Host
Rabbit
(28), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Enzyme Immunoassay (EIA), Western Blotting (WB)
(20), (11), (10), (9), (4), (1)
Pubmed 5 references available
Quantity 0.4 mL
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Catalog No. ABIN951662
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Immunogen KLH conjugated synthetic peptide between 244-274 amino acids from the C-terminal region of human COPS7A
Isotype Ig
Specificity This antibody reacts to COPS7A.
Cross-Reactivity (Details) Species reactivity (tested):Human.
Purification Affinity chromatography on Protein A
Alternative Name COPS7A
Background Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.Synonyms: COP9 signalosome complex subunit 7a, CSN7A, DERP10, Dermal papilla-derived protein 10, JAB1-containing signalosome subunit 7a, SGN7a, Signalosome subunit 7a
Molecular Weight 30277 Da
Gene ID 50813
NCBI Accession NP_001157565
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS, 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Background publications Groisman, Polanowska, Kuraoka et al.: "The ubiquitin ligase activity in the DDB2 and CSA complexes is differentially regulated by the COP9 signalosome in response to DNA damage." in: Cell, Vol. 113, Issue 3, pp. 357-67, 2003 (PubMed).

Wolf, Zhou, Wee: "The COP9 signalosome: an assembly and maintenance platform for cullin ubiquitin ligases?" in: Nature cell biology, Vol. 5, Issue 12, pp. 1029-33, 2003 (PubMed).

Obuse, Iwasaki, Kiyomitsu et al.: "A conserved Mis12 centromere complex is linked to heterochromatic HP1 and outer kinetochore protein Zwint-1." in: Nature cell biology, Vol. 6, Issue 11, pp. 1135-41, 2004 (PubMed).

Stelzl, Worm, Lalowski et al.: "A human protein-protein interaction network: a resource for annotating the proteome...." in: Cell, Vol. 122, Issue 6, pp. 957-68, 2005 (PubMed).

Matsuoka, Ballif, Smogorzewska et al.: "ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage." in: Science (New York, N.Y.), Vol. 316, Issue 5828, pp. 1160-6, 2007 (PubMed).

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