Leucyl/cystinyl Aminopeptidase (LNPEP) (N-Term), (AA 16-46) antibody

Details for Product No. ABIN953199
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Antigen
Synonyms fb73h12, wu:fb73h12, zgc:66103, 2010309L07Rik, 4732490P18Rik, CAP, IRAP, PLAP, gp160, vp165, P-LAP, Vp165, LNPEP
Epitope
N-Term, AA 16-46
(7), (6), (6), (2), (1), (1)
Reactivity
Human
(21), (4), (2)
Host
Rabbit
(20), (2), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1)
Application
Flow Cytometry (FACS), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(23), (17), (7), (6), (6), (3), (3), (2), (1), (1)
Pubmed 5 references available
Quantity 0.4 mL
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Catalog No. ABIN953199
357.50 $
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Immunogen KLH conjugated synthetic peptide between 16-46 amino acids from the N-terminal region of Human LNPEP. Genename: LNPEP
Specificity This antibody recognizes Human LNPEP (N-Term).
Purification Affinity Chromatography on Protein A
Alternative Name LNPEP
Background This gene encodes a zinc-dependent aminopeptidase that cleaves vasopressin, oxytocin, lys-bradykinin, met-enkephalin, dynorphin A and other peptide hormones. The protein can be secreted in maternal serum, reside in intracellular vesicles with the insulin-responsive glucose transporter GLUT4, or form a type II integral membrane glycoprotein. The protein catalyzes the final step in the conversion of angiotensinogen to angiotensin IV (AT4) and is also a receptor for AT4. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq].
Alternate names: Cystinyl aminopeptidase, EC=3.4.11.3, IRAP, Insulin-regulated membrane aminopeptidase, Insulin-responsive aminopeptidase, LNPEP, Leucyl-cystinyl aminopeptidase, OTASE, Oxytocinase, P-LAP, Placental leucine aminopeptidase
Molecular Weight 117349 Da
Gene ID 4012
NCBI Accession NP_005566
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS 0.09% Sodium Azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Expiry Date 12 months
Background publications Saveanu, Carroll, Weimershaus et al.: "IRAP identifies an endosomal compartment required for MHC class I cross-presentation." in: Science (New York, N.Y.), Vol. 325, Issue 5937, pp. 213-7, 2009 (PubMed).

Johnson, Roten, Dyer et al.: "The ERAP2 gene is associated with preeclampsia in Australian and Norwegian populations." in: Human genetics, Vol. 126, Issue 5, pp. 655-66, 2009 (PubMed).

Landau, Laverrière, Bischof et al.: "Alteration of circulating Placental Leucine Aminopeptidase (P-LAP) activity in preeclampsia." in: Neuro endocrinology letters, Vol. 31, Issue 1, pp. 63-6, 2010 (PubMed).

Williams, Mistry, Innes et al.: "Expression of AT1R, AT2R and AT4R and their roles in extravillous trophoblast invasion in the human." in: Placenta, Vol. 31, Issue 5, pp. 448-55, 2010 (PubMed).

Georgiadou, Hearn, Evnouchidou et al.: "Placental leucine aminopeptidase efficiently generates mature antigenic peptides in vitro but in patterns distinct from endoplasmic reticulum aminopeptidase 1." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 185, Issue 3, pp. 1584-92, 2010 (PubMed).

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